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In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico

BACKGROUND: Sonoran ethnic groups (Yaquis, Mayos, Seris, Guarijíos, Pimas, Kikapúes and Pápagos) use mainly herbal based preparations as their first line of medicinal treatment. Among the plants used are those with anti-tuberculosis properties; however, no formal research is available. METHODS: Orga...

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Autores principales: Robles-Zepeda, Ramón Enrique, Coronado-Aceves, Enrique Wenceslao, Velázquez-Contreras, Carlos Arturo, Ruiz-Bustos, Eduardo, Navarro-Navarro, Moisés, Garibay-Escobar, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222557/
https://www.ncbi.nlm.nih.gov/pubmed/24267469
http://dx.doi.org/10.1186/1472-6882-13-329
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author Robles-Zepeda, Ramón Enrique
Coronado-Aceves, Enrique Wenceslao
Velázquez-Contreras, Carlos Arturo
Ruiz-Bustos, Eduardo
Navarro-Navarro, Moisés
Garibay-Escobar, Adriana
author_facet Robles-Zepeda, Ramón Enrique
Coronado-Aceves, Enrique Wenceslao
Velázquez-Contreras, Carlos Arturo
Ruiz-Bustos, Eduardo
Navarro-Navarro, Moisés
Garibay-Escobar, Adriana
author_sort Robles-Zepeda, Ramón Enrique
collection PubMed
description BACKGROUND: Sonoran ethnic groups (Yaquis, Mayos, Seris, Guarijíos, Pimas, Kikapúes and Pápagos) use mainly herbal based preparations as their first line of medicinal treatment. Among the plants used are those with anti-tuberculosis properties; however, no formal research is available. METHODS: Organic extracts were obtained from nine medicinal plants traditionally used by Sonoran ethnic groups to treat different kinds of diseases; three of them are mainly used to treat tuberculosis. All of the extracts were tested against Mycobacterium tuberculosis H37Rv using the Alamar Blue redox bioassay. RESULTS: Methanolic extracts from Ambrosia confertiflora, Ambrosia ambrosioides and Guaiacum coulteri showed minimal inhibitory concentration (MIC) values of 200, 790 and 1000 μg/mL, respectively, whereas no effect was observed with the rest of the methanolic extracts at the concentrations tested. Chloroform, dichloromethane, and ethyl acetate extracts from Ambrosia confertiflora showed a MIC of 90, 120 and 160 μg/mL, respectively. CONCLUSIONS: A. confertiflora and A. ambrosioides showed the best anti-mycobacterial activity in vitro. The activity of Guaiacum coulteri is consistent with the traditional use by Sonoran ethnic groups as anti-tuberculosis agent. For these reasons, it is important to investigate a broader spectrum of medicinal plants in order to find compounds active against Mycobacterium tuberculosis.
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spelling pubmed-42225572014-11-07 In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico Robles-Zepeda, Ramón Enrique Coronado-Aceves, Enrique Wenceslao Velázquez-Contreras, Carlos Arturo Ruiz-Bustos, Eduardo Navarro-Navarro, Moisés Garibay-Escobar, Adriana BMC Complement Altern Med Research Article BACKGROUND: Sonoran ethnic groups (Yaquis, Mayos, Seris, Guarijíos, Pimas, Kikapúes and Pápagos) use mainly herbal based preparations as their first line of medicinal treatment. Among the plants used are those with anti-tuberculosis properties; however, no formal research is available. METHODS: Organic extracts were obtained from nine medicinal plants traditionally used by Sonoran ethnic groups to treat different kinds of diseases; three of them are mainly used to treat tuberculosis. All of the extracts were tested against Mycobacterium tuberculosis H37Rv using the Alamar Blue redox bioassay. RESULTS: Methanolic extracts from Ambrosia confertiflora, Ambrosia ambrosioides and Guaiacum coulteri showed minimal inhibitory concentration (MIC) values of 200, 790 and 1000 μg/mL, respectively, whereas no effect was observed with the rest of the methanolic extracts at the concentrations tested. Chloroform, dichloromethane, and ethyl acetate extracts from Ambrosia confertiflora showed a MIC of 90, 120 and 160 μg/mL, respectively. CONCLUSIONS: A. confertiflora and A. ambrosioides showed the best anti-mycobacterial activity in vitro. The activity of Guaiacum coulteri is consistent with the traditional use by Sonoran ethnic groups as anti-tuberculosis agent. For these reasons, it is important to investigate a broader spectrum of medicinal plants in order to find compounds active against Mycobacterium tuberculosis. BioMed Central 2013-11-25 /pmc/articles/PMC4222557/ /pubmed/24267469 http://dx.doi.org/10.1186/1472-6882-13-329 Text en Copyright © 2013 Robles-Zepeda et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Robles-Zepeda, Ramón Enrique
Coronado-Aceves, Enrique Wenceslao
Velázquez-Contreras, Carlos Arturo
Ruiz-Bustos, Eduardo
Navarro-Navarro, Moisés
Garibay-Escobar, Adriana
In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
title In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
title_full In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
title_fullStr In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
title_full_unstemmed In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
title_short In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
title_sort in vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in sonora, mexico
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222557/
https://www.ncbi.nlm.nih.gov/pubmed/24267469
http://dx.doi.org/10.1186/1472-6882-13-329
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