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In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico
BACKGROUND: Sonoran ethnic groups (Yaquis, Mayos, Seris, Guarijíos, Pimas, Kikapúes and Pápagos) use mainly herbal based preparations as their first line of medicinal treatment. Among the plants used are those with anti-tuberculosis properties; however, no formal research is available. METHODS: Orga...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222557/ https://www.ncbi.nlm.nih.gov/pubmed/24267469 http://dx.doi.org/10.1186/1472-6882-13-329 |
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author | Robles-Zepeda, Ramón Enrique Coronado-Aceves, Enrique Wenceslao Velázquez-Contreras, Carlos Arturo Ruiz-Bustos, Eduardo Navarro-Navarro, Moisés Garibay-Escobar, Adriana |
author_facet | Robles-Zepeda, Ramón Enrique Coronado-Aceves, Enrique Wenceslao Velázquez-Contreras, Carlos Arturo Ruiz-Bustos, Eduardo Navarro-Navarro, Moisés Garibay-Escobar, Adriana |
author_sort | Robles-Zepeda, Ramón Enrique |
collection | PubMed |
description | BACKGROUND: Sonoran ethnic groups (Yaquis, Mayos, Seris, Guarijíos, Pimas, Kikapúes and Pápagos) use mainly herbal based preparations as their first line of medicinal treatment. Among the plants used are those with anti-tuberculosis properties; however, no formal research is available. METHODS: Organic extracts were obtained from nine medicinal plants traditionally used by Sonoran ethnic groups to treat different kinds of diseases; three of them are mainly used to treat tuberculosis. All of the extracts were tested against Mycobacterium tuberculosis H37Rv using the Alamar Blue redox bioassay. RESULTS: Methanolic extracts from Ambrosia confertiflora, Ambrosia ambrosioides and Guaiacum coulteri showed minimal inhibitory concentration (MIC) values of 200, 790 and 1000 μg/mL, respectively, whereas no effect was observed with the rest of the methanolic extracts at the concentrations tested. Chloroform, dichloromethane, and ethyl acetate extracts from Ambrosia confertiflora showed a MIC of 90, 120 and 160 μg/mL, respectively. CONCLUSIONS: A. confertiflora and A. ambrosioides showed the best anti-mycobacterial activity in vitro. The activity of Guaiacum coulteri is consistent with the traditional use by Sonoran ethnic groups as anti-tuberculosis agent. For these reasons, it is important to investigate a broader spectrum of medicinal plants in order to find compounds active against Mycobacterium tuberculosis. |
format | Online Article Text |
id | pubmed-4222557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42225572014-11-07 In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico Robles-Zepeda, Ramón Enrique Coronado-Aceves, Enrique Wenceslao Velázquez-Contreras, Carlos Arturo Ruiz-Bustos, Eduardo Navarro-Navarro, Moisés Garibay-Escobar, Adriana BMC Complement Altern Med Research Article BACKGROUND: Sonoran ethnic groups (Yaquis, Mayos, Seris, Guarijíos, Pimas, Kikapúes and Pápagos) use mainly herbal based preparations as their first line of medicinal treatment. Among the plants used are those with anti-tuberculosis properties; however, no formal research is available. METHODS: Organic extracts were obtained from nine medicinal plants traditionally used by Sonoran ethnic groups to treat different kinds of diseases; three of them are mainly used to treat tuberculosis. All of the extracts were tested against Mycobacterium tuberculosis H37Rv using the Alamar Blue redox bioassay. RESULTS: Methanolic extracts from Ambrosia confertiflora, Ambrosia ambrosioides and Guaiacum coulteri showed minimal inhibitory concentration (MIC) values of 200, 790 and 1000 μg/mL, respectively, whereas no effect was observed with the rest of the methanolic extracts at the concentrations tested. Chloroform, dichloromethane, and ethyl acetate extracts from Ambrosia confertiflora showed a MIC of 90, 120 and 160 μg/mL, respectively. CONCLUSIONS: A. confertiflora and A. ambrosioides showed the best anti-mycobacterial activity in vitro. The activity of Guaiacum coulteri is consistent with the traditional use by Sonoran ethnic groups as anti-tuberculosis agent. For these reasons, it is important to investigate a broader spectrum of medicinal plants in order to find compounds active against Mycobacterium tuberculosis. BioMed Central 2013-11-25 /pmc/articles/PMC4222557/ /pubmed/24267469 http://dx.doi.org/10.1186/1472-6882-13-329 Text en Copyright © 2013 Robles-Zepeda et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Robles-Zepeda, Ramón Enrique Coronado-Aceves, Enrique Wenceslao Velázquez-Contreras, Carlos Arturo Ruiz-Bustos, Eduardo Navarro-Navarro, Moisés Garibay-Escobar, Adriana In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico |
title | In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico |
title_full | In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico |
title_fullStr | In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico |
title_full_unstemmed | In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico |
title_short | In vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in Sonora, Mexico |
title_sort | in vitro anti-mycobacterial activity of nine medicinal plants used by ethnic groups in sonora, mexico |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222557/ https://www.ncbi.nlm.nih.gov/pubmed/24267469 http://dx.doi.org/10.1186/1472-6882-13-329 |
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