Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China

BACKGROUND: An influenza H3N2 epidemic occurred throughout Southern China in 2012. METHODS: We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011–2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylatio...

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Detalles Bibliográficos
Autores principales: Zhong, Jing, Liang, Lijun, Huang, Ping, Zhu, Xiaolan, Zou, Lirong, Yu, Shouyi, Zhang, Xin, Zhang, Yonghui, Ni, Hanzhong, Yan, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222568/
https://www.ncbi.nlm.nih.gov/pubmed/24279698
http://dx.doi.org/10.1186/1743-422X-10-345
Descripción
Sumario:BACKGROUND: An influenza H3N2 epidemic occurred throughout Southern China in 2012. METHODS: We analyzed the hemagglutinin (HA) and neuraminidase (NA) genes of influenza H3N2 strains isolated between 2011–2012 from Guangdong. Mutation sites, evolutionary selection, antigenic sites, and N-glycosylation within these strains were analyzed. RESULTS: The 2011–2012 Guangdong strains contained the HA-A214S, HA-V239I, HA-N328S, NA-L81P, and NA-D93G mutations, similar to those seen in the A/ Perth/16/2009 influenza strain. The HA-NSS(061–063) and NNS(160–162) glycosylation sites were prevalent among the 2011–2012 Guangdong strains but the NA-NRS(402–404) site was deleted. Antigenically, there was a four-fold difference between A/Perth/16/2009 -like strains and the 2011–2012 Guangdong strains. CONCLUSION: Antigenic drift of the H3N2 subtype contributed to the occurrence of the Southern China influenza epidemic of 2012.

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