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Impaired noradrenaline homeostasis in rats with painful diabetic neuropathy as a target of duloxetine analgesia

BACKGROUND: Painful diabetic neuropathy (PDN) is a serious complication of diabetes mellitus that affects a large number of patients in many countries. The molecular mechanisms underlying the exaggerated nociception in PDN have not been established. Recently, duloxetine (DLX), a serotonin and noradr...

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Detalles Bibliográficos
Autores principales: Kinoshita, Jun, Takahashi, Yukari, Watabe, Ayako M, Utsunomiya, Kazunori, Kato, Fusao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222693/
https://www.ncbi.nlm.nih.gov/pubmed/24279796
http://dx.doi.org/10.1186/1744-8069-9-59