Cargando…

The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China

BACKGROUND: bla(CTX-M-15), the most widely distributed gene encoding extended-spectrum β-lactamases globally, was not common in China. This study was performed to characterize bla(CTX-M-15)-carrying Escherichia coli in western China. FINDINGS: Out of 144 Escherichia coli isolates from 20 hospitals i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lei, Lü, Xiaoju, Zong, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222882/
https://www.ncbi.nlm.nih.gov/pubmed/24279763
http://dx.doi.org/10.1186/1476-0711-12-35
_version_ 1782343125087289344
author Zhang, Lei
Lü, Xiaoju
Zong, Zhiyong
author_facet Zhang, Lei
Lü, Xiaoju
Zong, Zhiyong
author_sort Zhang, Lei
collection PubMed
description BACKGROUND: bla(CTX-M-15), the most widely distributed gene encoding extended-spectrum β-lactamases globally, was not common in China. This study was performed to characterize bla(CTX-M-15)-carrying Escherichia coli in western China. FINDINGS: Out of 144 Escherichia coli isolates from 20 hospitals in western China, 8 were found carrying bla(CTX-M-15). bla(CTX-M-15) was carried by isolates of ST131and 5 new STs (ST3342, ST3513, ST3516, ST3517 and ST3518). The 5 new STs shared 5 identical alleles out of 7 but only had up to 2 alleles identical to ST131. bla(CTX-M-15) was located on plasmids of IncI1 (ST16) or IncFII-related group (four replicon types). The co-transfer of a few antimicrobial resistance genes including qnrA, qnrB, qnrS, qepA, aac (6′)-Ib-cr, aac (3)-II, tetA, bla(TEM) and bla(OXA-1) with bla(CTX-M-15) were examined but only bla(TEM-1) was found co-transferring with bla(CTX-M-15). CONCLUSIONS: Five new STs of E. coli and three new types of IncFII-related plasmids carrying bla(CTX-M-15) were identified. This study together with several reports suggested that bla(CTX-M-15) has emerged in China and the interruption of both vertical and horizontal transmission of bla(CTX-M-15) is required to hurdle its further spread.
format Online
Article
Text
id pubmed-4222882
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-42228822014-11-07 The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China Zhang, Lei Lü, Xiaoju Zong, Zhiyong Ann Clin Microbiol Antimicrob Short Report BACKGROUND: bla(CTX-M-15), the most widely distributed gene encoding extended-spectrum β-lactamases globally, was not common in China. This study was performed to characterize bla(CTX-M-15)-carrying Escherichia coli in western China. FINDINGS: Out of 144 Escherichia coli isolates from 20 hospitals in western China, 8 were found carrying bla(CTX-M-15). bla(CTX-M-15) was carried by isolates of ST131and 5 new STs (ST3342, ST3513, ST3516, ST3517 and ST3518). The 5 new STs shared 5 identical alleles out of 7 but only had up to 2 alleles identical to ST131. bla(CTX-M-15) was located on plasmids of IncI1 (ST16) or IncFII-related group (four replicon types). The co-transfer of a few antimicrobial resistance genes including qnrA, qnrB, qnrS, qepA, aac (6′)-Ib-cr, aac (3)-II, tetA, bla(TEM) and bla(OXA-1) with bla(CTX-M-15) were examined but only bla(TEM-1) was found co-transferring with bla(CTX-M-15). CONCLUSIONS: Five new STs of E. coli and three new types of IncFII-related plasmids carrying bla(CTX-M-15) were identified. This study together with several reports suggested that bla(CTX-M-15) has emerged in China and the interruption of both vertical and horizontal transmission of bla(CTX-M-15) is required to hurdle its further spread. BioMed Central 2013-11-27 /pmc/articles/PMC4222882/ /pubmed/24279763 http://dx.doi.org/10.1186/1476-0711-12-35 Text en Copyright © 2013 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Zhang, Lei
Lü, Xiaoju
Zong, Zhiyong
The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China
title The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China
title_full The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China
title_fullStr The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China
title_full_unstemmed The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China
title_short The emergence of bla(CTX-M-15)-carrying Escherichia coli of ST131 and new sequence types in Western China
title_sort emergence of bla(ctx-m-15)-carrying escherichia coli of st131 and new sequence types in western china
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222882/
https://www.ncbi.nlm.nih.gov/pubmed/24279763
http://dx.doi.org/10.1186/1476-0711-12-35
work_keys_str_mv AT zhanglei theemergenceofblactxm15carryingescherichiacoliofst131andnewsequencetypesinwesternchina
AT luxiaoju theemergenceofblactxm15carryingescherichiacoliofst131andnewsequencetypesinwesternchina
AT zongzhiyong theemergenceofblactxm15carryingescherichiacoliofst131andnewsequencetypesinwesternchina
AT zhanglei emergenceofblactxm15carryingescherichiacoliofst131andnewsequencetypesinwesternchina
AT luxiaoju emergenceofblactxm15carryingescherichiacoliofst131andnewsequencetypesinwesternchina
AT zongzhiyong emergenceofblactxm15carryingescherichiacoliofst131andnewsequencetypesinwesternchina