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Cell Proliferation and Neurogenesis in Adult Mouse Brain

Neurogenesis, the formation of new neurons, can be observed in the adult brain of many mammalian species, including humans. Despite significant progress in our understanding of adult neurogenesis, we are still missing data about the extent and location of production of neural precursors in the adult...

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Autores principales: Bordiuk, Olivia L., Smith, Karen, Morin, Peter J., Semënov, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222938/
https://www.ncbi.nlm.nih.gov/pubmed/25375658
http://dx.doi.org/10.1371/journal.pone.0111453
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author Bordiuk, Olivia L.
Smith, Karen
Morin, Peter J.
Semënov, Mikhail V.
author_facet Bordiuk, Olivia L.
Smith, Karen
Morin, Peter J.
Semënov, Mikhail V.
author_sort Bordiuk, Olivia L.
collection PubMed
description Neurogenesis, the formation of new neurons, can be observed in the adult brain of many mammalian species, including humans. Despite significant progress in our understanding of adult neurogenesis, we are still missing data about the extent and location of production of neural precursors in the adult mammalian brain. We used 5-ethynyl-2'-deoxyuridine (EdU) to map the location of proliferating cells throughout the entire adult mouse brain and found that neurogenesis occurs at two locations in the mouse brain. The larger one we define as the main proliferative zone (MPZ), and the smaller one corresponds to the subgranular zone of the hippocampus. The MPZ can be divided into three parts. The caudate migratory stream (CMS) occupies the middle part of the MPZ. The cable of proliferating cells emanating from the most anterior part of the CMS toward the olfactory bulbs forms the rostral migratory stream. The thin layer of proliferating cells extending posteriorly from the CMS forms the midlayer. We have not found any additional aggregations of proliferating cells in the adult mouse brain that could suggest the existence of other major neurogenic zones in the adult mouse brain.
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spelling pubmed-42229382014-11-13 Cell Proliferation and Neurogenesis in Adult Mouse Brain Bordiuk, Olivia L. Smith, Karen Morin, Peter J. Semënov, Mikhail V. PLoS One Research Article Neurogenesis, the formation of new neurons, can be observed in the adult brain of many mammalian species, including humans. Despite significant progress in our understanding of adult neurogenesis, we are still missing data about the extent and location of production of neural precursors in the adult mammalian brain. We used 5-ethynyl-2'-deoxyuridine (EdU) to map the location of proliferating cells throughout the entire adult mouse brain and found that neurogenesis occurs at two locations in the mouse brain. The larger one we define as the main proliferative zone (MPZ), and the smaller one corresponds to the subgranular zone of the hippocampus. The MPZ can be divided into three parts. The caudate migratory stream (CMS) occupies the middle part of the MPZ. The cable of proliferating cells emanating from the most anterior part of the CMS toward the olfactory bulbs forms the rostral migratory stream. The thin layer of proliferating cells extending posteriorly from the CMS forms the midlayer. We have not found any additional aggregations of proliferating cells in the adult mouse brain that could suggest the existence of other major neurogenic zones in the adult mouse brain. Public Library of Science 2014-11-06 /pmc/articles/PMC4222938/ /pubmed/25375658 http://dx.doi.org/10.1371/journal.pone.0111453 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Bordiuk, Olivia L.
Smith, Karen
Morin, Peter J.
Semënov, Mikhail V.
Cell Proliferation and Neurogenesis in Adult Mouse Brain
title Cell Proliferation and Neurogenesis in Adult Mouse Brain
title_full Cell Proliferation and Neurogenesis in Adult Mouse Brain
title_fullStr Cell Proliferation and Neurogenesis in Adult Mouse Brain
title_full_unstemmed Cell Proliferation and Neurogenesis in Adult Mouse Brain
title_short Cell Proliferation and Neurogenesis in Adult Mouse Brain
title_sort cell proliferation and neurogenesis in adult mouse brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222938/
https://www.ncbi.nlm.nih.gov/pubmed/25375658
http://dx.doi.org/10.1371/journal.pone.0111453
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