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Multiple Functional Risk Variants in a SMAD7 Enhancer Implicate a Colorectal Cancer Risk Haplotype

Genome-wide association studies (GWAS) of colorectal cancer (CRC) have led to the identification of a number of common variants associated with modest risk. Several risk variants map within the vicinity of TGFβ/BMP signaling pathway genes, including rs4939827 within an intron of SMAD7 at 18q21.1. A...

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Detalles Bibliográficos
Autores principales:	Fortini, Barbara K., Tring, Stephanie, Plummer, Sarah J., Edlund, Christopher K., Moreno, Victor, Bresalier, Robert S., Barry, Elizabeth L., Church, Timothy R., Figueiredo, Jane C., Casey, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223076/ https://www.ncbi.nlm.nih.gov/pubmed/25375357 http://dx.doi.org/10.1371/journal.pone.0111914

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