ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete...

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Detalles Bibliográficos
Autores principales: Chung, Dawoon, Barker, Bridget M., Carey, Charles C., Merriman, Brittney, Werner, Ernst R., Lechner, Beatrix E., Dhingra, Sourabh, Cheng, Chao, Xu, Wenjie, Blosser, Sara J., Morohashi, Kengo, Mazurie, Aurélien, Mitchell, Thomas K., Haas, Hubertus, Mitchell, Aaron P., Cramer, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223079/
https://www.ncbi.nlm.nih.gov/pubmed/25375670
http://dx.doi.org/10.1371/journal.ppat.1004487

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