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Targeted enzyme prodrug therapy for metastatic prostate cancer – a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase

BACKGROUND: Enzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion proteins targeted via annexin V to phosphatidylserine exposed on the tumor vascu...

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Detalles Bibliográficos
Autores principales:	Guillen, Katrin P, Kurkjian, Carla, Harrison, Roger G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223417/ https://www.ncbi.nlm.nih.gov/pubmed/25047949 http://dx.doi.org/10.1186/s12929-014-0065-3

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