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Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

BACKGROUND: Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here we study the anti-tumor activity of the metal chelator, TPEN, and define its m...

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Detalles Bibliográficos
Autores principales:	Fatfat, Maamoun, Merhi, Raghida Abou, Rahal, Omar, Stoyanovsky, Detcho A, Zaki, Angela, Haidar, Hazar, Kagan, Valerian E, Gali-Muhtasib, Hala, Machaca, Khaled
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223620/ https://www.ncbi.nlm.nih.gov/pubmed/25047035 http://dx.doi.org/10.1186/1471-2407-14-527

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