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Sleep disturbance, depression and pain in adults with sickle cell disease

BACKGROUND: Sleep disturbance and depression are commonly encountered in primary care. In sickle cell disease, depression is associated with pain, poor treatment compliance, and lower quality of life. The prevalence of sleep disturbance and its effect upon quality of life in adults with sickle cell...

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Autores principales: Wallen, Gwenyth R, Minniti, Caterina P, Krumlauf, Michael, Eckes, Ellen, Allen, Darlene, Oguhebe, Anna, Seamon, Cassie, Darbari, Deepika S, Hildesheim, Mariana, Yang, Li, Schulden, Jeffrey D, Kato, Gregory J, Taylor VI, James G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223647/
https://www.ncbi.nlm.nih.gov/pubmed/25047658
http://dx.doi.org/10.1186/1471-244X-14-207
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author Wallen, Gwenyth R
Minniti, Caterina P
Krumlauf, Michael
Eckes, Ellen
Allen, Darlene
Oguhebe, Anna
Seamon, Cassie
Darbari, Deepika S
Hildesheim, Mariana
Yang, Li
Schulden, Jeffrey D
Kato, Gregory J
Taylor VI, James G
author_facet Wallen, Gwenyth R
Minniti, Caterina P
Krumlauf, Michael
Eckes, Ellen
Allen, Darlene
Oguhebe, Anna
Seamon, Cassie
Darbari, Deepika S
Hildesheim, Mariana
Yang, Li
Schulden, Jeffrey D
Kato, Gregory J
Taylor VI, James G
author_sort Wallen, Gwenyth R
collection PubMed
description BACKGROUND: Sleep disturbance and depression are commonly encountered in primary care. In sickle cell disease, depression is associated with pain, poor treatment compliance, and lower quality of life. The prevalence of sleep disturbance and its effect upon quality of life in adults with sickle cell disease is unknown. The goal of this study was to determine the prevalence of sleep disturbance and if it is associated with pain and depression in sickle cell disease. METHODS: Three hundred twenty eight adults with sickle cell disease enrolled on the Bethesda Sickle Cell Cohort Study were assessed using the Pittsburgh Sleep Quality Index and Beck Depression Inventory II screening measures as a cross-sectional survey. Scores greater than 5 (Pittsburgh Sleep Quality Index) and 16 (Beck Depression Inventory II) defined sleep disturbance and depression, respectively. Clinical and laboratory parameters were also assessed. RESULTS: The mean Pittsburgh Sleep Quality Index score was 8.4 (SD ± 4.2) indicating a 71.2% prevalence of sleep disturbance. The mean Beck Depression Inventory II score was 8.0 (SD ± 8.9). Sixty five (20.6%) participants had a score indicating depression, and half of these (10.0%) had thoughts of suicide. Both Pittsburgh Sleep Quality Index and Beck Depression Inventory II scores were significantly correlated (p < .001). The number of days with mild/moderate pain (p = .001) and a history of headaches (p = .005) were independently associated with depression by multivariate regression analysis. Patients with sleep disturbance were older (p = .002), had higher body mass index (p = .011), had more days of pain (p = .003) and more frequent severe acute painful events (emergency room visits and hospitalizations) during the previous 12 months (p < .001). CONCLUSIONS: More than 70 percent of adults with sickle cell disease had sleep disturbance, while 21 percent showed evidence of clinical depression. Sleep disturbance and depression were correlated, and were most common among those with more frequent pain. Providers caring for adults with sickle cell disease and frequent pain should consider screening for these common co-morbidities. Additional study is needed to confirm these findings and to determine if treatments for pain, depression or sleep disturbances will improve quality of life measures in this patient population. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00011648.
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spelling pubmed-42236472014-11-08 Sleep disturbance, depression and pain in adults with sickle cell disease Wallen, Gwenyth R Minniti, Caterina P Krumlauf, Michael Eckes, Ellen Allen, Darlene Oguhebe, Anna Seamon, Cassie Darbari, Deepika S Hildesheim, Mariana Yang, Li Schulden, Jeffrey D Kato, Gregory J Taylor VI, James G BMC Psychiatry Research Article BACKGROUND: Sleep disturbance and depression are commonly encountered in primary care. In sickle cell disease, depression is associated with pain, poor treatment compliance, and lower quality of life. The prevalence of sleep disturbance and its effect upon quality of life in adults with sickle cell disease is unknown. The goal of this study was to determine the prevalence of sleep disturbance and if it is associated with pain and depression in sickle cell disease. METHODS: Three hundred twenty eight adults with sickle cell disease enrolled on the Bethesda Sickle Cell Cohort Study were assessed using the Pittsburgh Sleep Quality Index and Beck Depression Inventory II screening measures as a cross-sectional survey. Scores greater than 5 (Pittsburgh Sleep Quality Index) and 16 (Beck Depression Inventory II) defined sleep disturbance and depression, respectively. Clinical and laboratory parameters were also assessed. RESULTS: The mean Pittsburgh Sleep Quality Index score was 8.4 (SD ± 4.2) indicating a 71.2% prevalence of sleep disturbance. The mean Beck Depression Inventory II score was 8.0 (SD ± 8.9). Sixty five (20.6%) participants had a score indicating depression, and half of these (10.0%) had thoughts of suicide. Both Pittsburgh Sleep Quality Index and Beck Depression Inventory II scores were significantly correlated (p < .001). The number of days with mild/moderate pain (p = .001) and a history of headaches (p = .005) were independently associated with depression by multivariate regression analysis. Patients with sleep disturbance were older (p = .002), had higher body mass index (p = .011), had more days of pain (p = .003) and more frequent severe acute painful events (emergency room visits and hospitalizations) during the previous 12 months (p < .001). CONCLUSIONS: More than 70 percent of adults with sickle cell disease had sleep disturbance, while 21 percent showed evidence of clinical depression. Sleep disturbance and depression were correlated, and were most common among those with more frequent pain. Providers caring for adults with sickle cell disease and frequent pain should consider screening for these common co-morbidities. Additional study is needed to confirm these findings and to determine if treatments for pain, depression or sleep disturbances will improve quality of life measures in this patient population. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00011648. BioMed Central 2014-07-21 /pmc/articles/PMC4223647/ /pubmed/25047658 http://dx.doi.org/10.1186/1471-244X-14-207 Text en Copyright © 2014 Wallen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wallen, Gwenyth R
Minniti, Caterina P
Krumlauf, Michael
Eckes, Ellen
Allen, Darlene
Oguhebe, Anna
Seamon, Cassie
Darbari, Deepika S
Hildesheim, Mariana
Yang, Li
Schulden, Jeffrey D
Kato, Gregory J
Taylor VI, James G
Sleep disturbance, depression and pain in adults with sickle cell disease
title Sleep disturbance, depression and pain in adults with sickle cell disease
title_full Sleep disturbance, depression and pain in adults with sickle cell disease
title_fullStr Sleep disturbance, depression and pain in adults with sickle cell disease
title_full_unstemmed Sleep disturbance, depression and pain in adults with sickle cell disease
title_short Sleep disturbance, depression and pain in adults with sickle cell disease
title_sort sleep disturbance, depression and pain in adults with sickle cell disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223647/
https://www.ncbi.nlm.nih.gov/pubmed/25047658
http://dx.doi.org/10.1186/1471-244X-14-207
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