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Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases
ABSTRACT: BACKGROUND: Despite great improvement in the surgical treatment and adjunctive therapy for oral squamous cell carcinoma (OSCC), prognosis remains dismal in advanced cases. Regional metastatic disease is known to reduce recurrence free survival and disease specific survival significantly. T...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223686/ https://www.ncbi.nlm.nih.gov/pubmed/25047112 http://dx.doi.org/10.1186/1746-1596-9-145 |
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author | Balasundaram, Partheeban Singh, Manoj Kumar Dinda, Amit Kumar Thakar, Alok Yadav, Rajni |
author_facet | Balasundaram, Partheeban Singh, Manoj Kumar Dinda, Amit Kumar Thakar, Alok Yadav, Rajni |
author_sort | Balasundaram, Partheeban |
collection | PubMed |
description | ABSTRACT: BACKGROUND: Despite great improvement in the surgical treatment and adjunctive therapy for oral squamous cell carcinoma (OSCC), prognosis remains dismal in advanced cases. Regional metastatic disease is known to reduce recurrence free survival and disease specific survival significantly. The present study was conducted to evaluate the role of cell adhesion molecules β-catenin, E-cadherin and vimentin in predicting tumour metastasis of OSCC. METHODS: A total of sixty cases of oral squamous cell carcinoma were included for the study which comprised of 30 cases with lymph node metastases and 30 cases without metastases. Immunohistochemistry was performed for β-catenin, E-cadherin and vimentin on both the test groups along with 30 controls from normal buccal mucosa and inflammatory lesions each. RESULTS: There was no significant difference between the immunoreactivity for β-catenin, E-cadherin and vimentin between OSCC with and without lymph node metastases. Vimentin immunopositivity was noted with varying intensity in all cases of OSCC. CONCLUSIONS: E-cadherin and β-catenin are probably not the key determinants for regional metastases in OSCC. The role of vimentin expression in OSCC and metastases is controversial and needs to be studied further. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6506095201182002. |
format | Online Article Text |
id | pubmed-4223686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42236862014-11-08 Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases Balasundaram, Partheeban Singh, Manoj Kumar Dinda, Amit Kumar Thakar, Alok Yadav, Rajni Diagn Pathol Research ABSTRACT: BACKGROUND: Despite great improvement in the surgical treatment and adjunctive therapy for oral squamous cell carcinoma (OSCC), prognosis remains dismal in advanced cases. Regional metastatic disease is known to reduce recurrence free survival and disease specific survival significantly. The present study was conducted to evaluate the role of cell adhesion molecules β-catenin, E-cadherin and vimentin in predicting tumour metastasis of OSCC. METHODS: A total of sixty cases of oral squamous cell carcinoma were included for the study which comprised of 30 cases with lymph node metastases and 30 cases without metastases. Immunohistochemistry was performed for β-catenin, E-cadherin and vimentin on both the test groups along with 30 controls from normal buccal mucosa and inflammatory lesions each. RESULTS: There was no significant difference between the immunoreactivity for β-catenin, E-cadherin and vimentin between OSCC with and without lymph node metastases. Vimentin immunopositivity was noted with varying intensity in all cases of OSCC. CONCLUSIONS: E-cadherin and β-catenin are probably not the key determinants for regional metastases in OSCC. The role of vimentin expression in OSCC and metastases is controversial and needs to be studied further. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6506095201182002. BioMed Central 2014-07-21 /pmc/articles/PMC4223686/ /pubmed/25047112 http://dx.doi.org/10.1186/1746-1596-9-145 Text en Copyright © 2014 Balasundaram et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Balasundaram, Partheeban Singh, Manoj Kumar Dinda, Amit Kumar Thakar, Alok Yadav, Rajni Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
title | Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
title_full | Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
title_fullStr | Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
title_full_unstemmed | Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
title_short | Study of β-catenin, E-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
title_sort | study of β-catenin, e-cadherin and vimentin in oral squamous cell carcinoma with and without lymph node metastases |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223686/ https://www.ncbi.nlm.nih.gov/pubmed/25047112 http://dx.doi.org/10.1186/1746-1596-9-145 |
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