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Combinatorial Modulation of Signaling Pathways Reveals Cell-Type-Specific Requirements for Highly Efficient and Synchronous iPSC Reprogramming

The differentiated state of somatic cells provides barriers for the derivation of induced pluripotent stem cells (iPSCs). To address why some cell types reprogram more readily than others, we studied the effect of combined modulation of cellular signaling pathways. Surprisingly, inhibition of transf...

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Detalles Bibliográficos
Autores principales:	Vidal, Simon E., Amlani, Bhishma, Chen, Taotao, Tsirigos, Aristotelis, Stadtfeld, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223696/ https://www.ncbi.nlm.nih.gov/pubmed/25358786 http://dx.doi.org/10.1016/j.stemcr.2014.08.003

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