Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation

Silencing of the FMR1 gene leads to fragile X syndrome, the most common cause of inherited intellectual disability. To study the epigenetic modifications of the FMR1 gene during silencing in time, we used fibroblasts and induced pluripotent stem cells (iPSCs) of an unmethylated full mutation (uFM) i...

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Detalles Bibliográficos
Autores principales: de Esch, Celine E.F., Ghazvini, Mehrnaz, Loos, Friedemann, Schelling-Kazaryan, Nune, Widagdo, W., Munshi, Shashini T., van der Wal, Erik, Douben, Hannie, Gunhanlar, Nilhan, Kushner, Steven A., Pijnappel, W.W.M. Pim, de Vrij, Femke M.S., Geijsen, Niels, Gribnau, Joost, Willemsen, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223701/
https://www.ncbi.nlm.nih.gov/pubmed/25358783
http://dx.doi.org/10.1016/j.stemcr.2014.07.013

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