In vitro adherence of Candida albicans isolated from patients with chronic periodontitis

Adherence is considered an extremely important virulence factor in yeast. OBJECTIVE: The aim of this study was to analyze the adherence to epithelial cells of C. albicans isolated from patients with chronic periodontitis in comparison to healthy patients. MATERIAL AND METHODS: Candida albicans cells...

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Detalles Bibliográficos
Autores principales: MACHADO, Adriana Gadotti, KOMIYAMA, Edson Yukio, dos SANTOS, Silvana Soléo Ferreira, JORGE, Antonio Olavo Cardoso, BRIGHENTI, Fernanda Lourenção, KOGA-ITO, Cristiane Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculdade de Odontologia de Bauru da Universidade de São Paulo 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223791/
https://www.ncbi.nlm.nih.gov/pubmed/21710096
http://dx.doi.org/10.1590/S1678-77572011005000014
Descripción
Sumario:Adherence is considered an extremely important virulence factor in yeast. OBJECTIVE: The aim of this study was to analyze the adherence to epithelial cells of C. albicans isolated from patients with chronic periodontitis in comparison to healthy patients. MATERIAL AND METHODS: Candida albicans cells isolated from individuals with chronic periodontitis (n=25) and healthy controls (n=25) were included in this study. Suspensions of C. albicans (10(6) cells/mL) and epithelial cells (10(5) cells/mL) were mixed and incubated at 37ºC for 1 h. The number of yeasts adhered to 25 epithelial cells was counted. RESULTS: The number of C. albicans cells adhered to epithelial cells was statistically higher in the chronic periodontitis group than in the control group (Student's t-test, p=0.000). CONCLUSION: The results of the present study suggest a higher Candida adherence of samples isolated from patients with chronic periodontitis.

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