Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole

Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, whic...

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Autores principales: Chen, Jia, Chen, Feng, Wang, Ying, Yang, Ling-Yi, Miao, Miao, Han, Yue, Wu, De-Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223824/
https://www.ncbi.nlm.nih.gov/pubmed/25383317
http://dx.doi.org/10.1016/j.mmcr.2014.09.003
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author Chen, Jia
Chen, Feng
Wang, Ying
Yang, Ling-Yi
Miao, Miao
Han, Yue
Wu, De-Pei
author_facet Chen, Jia
Chen, Feng
Wang, Ying
Yang, Ling-Yi
Miao, Miao
Han, Yue
Wu, De-Pei
author_sort Chen, Jia
collection PubMed
description Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B (AmB) plus caspofungin – in which liposomal AmB dose was reduced due to renal toxicity – was administered to successfully treat this patient.
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spelling pubmed-42238242014-11-09 Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole Chen, Jia Chen, Feng Wang, Ying Yang, Ling-Yi Miao, Miao Han, Yue Wu, De-Pei Med Mycol Case Rep Article Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B (AmB) plus caspofungin – in which liposomal AmB dose was reduced due to renal toxicity – was administered to successfully treat this patient. Elsevier 2014-10-19 /pmc/articles/PMC4223824/ /pubmed/25383317 http://dx.doi.org/10.1016/j.mmcr.2014.09.003 Text en © 2014 International Society for Human and Animal Mycology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Chen, Jia
Chen, Feng
Wang, Ying
Yang, Ling-Yi
Miao, Miao
Han, Yue
Wu, De-Pei
Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
title Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
title_full Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
title_fullStr Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
title_full_unstemmed Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
title_short Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole
title_sort use of combination therapy to successfully treat breakthrough trichosporon asahii infection in an acute leukemia patient receiving voriconazole
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223824/
https://www.ncbi.nlm.nih.gov/pubmed/25383317
http://dx.doi.org/10.1016/j.mmcr.2014.09.003
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