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Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients

BACKGROUND: Understanding the possible role of visfatin in the pathogenesis of beta-thalassemia major (BTM) and its relationship with markers of endothelial function could help us to provide more effective therapeutic approaches for treatment of patients with BTM and its related complications. The a...

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Autores principales: Dehkordi, Elham Hashemi, Nourbakhsh, Seyed Mohammad Kazem, Rostampour, Noushin, Boroujeni, Fateme Alizadeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223946/
https://www.ncbi.nlm.nih.gov/pubmed/25400885
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author Dehkordi, Elham Hashemi
Nourbakhsh, Seyed Mohammad Kazem
Rostampour, Noushin
Boroujeni, Fateme Alizadeh
author_facet Dehkordi, Elham Hashemi
Nourbakhsh, Seyed Mohammad Kazem
Rostampour, Noushin
Boroujeni, Fateme Alizadeh
author_sort Dehkordi, Elham Hashemi
collection PubMed
description BACKGROUND: Understanding the possible role of visfatin in the pathogenesis of beta-thalassemia major (BTM) and its relationship with markers of endothelial function could help us to provide more effective therapeutic approaches for treatment of patients with BTM and its related complications. The aim of current study was to compare serum level of visfatin between patients with BTM and control group and determine its correlation with markers of endothelial function, intracellular adhesion molecule (ICAM) and vascular adhesion molecule (VCAM). METHODS: In this case-control study, patients with BTM receiving regular blood transfusion aged 10-20 years and a group of healthy subjects were enrolled. Selected subjects examined clinically and venous blood samples obtained for visfatin, ICAM, VCAM, cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and ferritin measurements. Mean (standard deviation) of studied laboratory measurements compared in two studied groups and the relation between visfatin and ICAM, VCAM, ferrittin, body mass index determined. RESULTS: In this study 31 patients with BTM and 30 healthy controls studied. Mean of visfatin was significantly higher in patients with BTM than control group (133.9 ± 60.1 vs. 43.3 ± 27.9, P < 0.001). CONCLUSIONS: The higher level of visfatin among patients with BTM indicated the possible inflammatory role of this adipocytokine in BTM. It seems that for understanding the underlying mechanisms and its relation with vascular inflammatory markers and endothelial function further studies with larger sample size is needed.
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spelling pubmed-42239462014-11-14 Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients Dehkordi, Elham Hashemi Nourbakhsh, Seyed Mohammad Kazem Rostampour, Noushin Boroujeni, Fateme Alizadeh Int J Prev Med Original Article BACKGROUND: Understanding the possible role of visfatin in the pathogenesis of beta-thalassemia major (BTM) and its relationship with markers of endothelial function could help us to provide more effective therapeutic approaches for treatment of patients with BTM and its related complications. The aim of current study was to compare serum level of visfatin between patients with BTM and control group and determine its correlation with markers of endothelial function, intracellular adhesion molecule (ICAM) and vascular adhesion molecule (VCAM). METHODS: In this case-control study, patients with BTM receiving regular blood transfusion aged 10-20 years and a group of healthy subjects were enrolled. Selected subjects examined clinically and venous blood samples obtained for visfatin, ICAM, VCAM, cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and ferritin measurements. Mean (standard deviation) of studied laboratory measurements compared in two studied groups and the relation between visfatin and ICAM, VCAM, ferrittin, body mass index determined. RESULTS: In this study 31 patients with BTM and 30 healthy controls studied. Mean of visfatin was significantly higher in patients with BTM than control group (133.9 ± 60.1 vs. 43.3 ± 27.9, P < 0.001). CONCLUSIONS: The higher level of visfatin among patients with BTM indicated the possible inflammatory role of this adipocytokine in BTM. It seems that for understanding the underlying mechanisms and its relation with vascular inflammatory markers and endothelial function further studies with larger sample size is needed. Medknow Publications & Media Pvt Ltd 2014-10 /pmc/articles/PMC4223946/ /pubmed/25400885 Text en Copyright: © International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Dehkordi, Elham Hashemi
Nourbakhsh, Seyed Mohammad Kazem
Rostampour, Noushin
Boroujeni, Fateme Alizadeh
Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients
title Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients
title_full Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients
title_fullStr Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients
title_full_unstemmed Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients
title_short Relationship between Serum Visfatin and Vascular Inflammation Markers Level in Beta Thalassemia Major Patients
title_sort relationship between serum visfatin and vascular inflammation markers level in beta thalassemia major patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223946/
https://www.ncbi.nlm.nih.gov/pubmed/25400885
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