Methylphenidate enhances neural stem cell differentiation

BACKGROUND: The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the...

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Autores principales: Bartl, Jasmin, Mori, Takatoshi, Riederer, Peter, Ozawa, Hiroki, Grünblatt, Edna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224010/
https://www.ncbi.nlm.nih.gov/pubmed/25408898
http://dx.doi.org/10.1186/2049-9256-1-5
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author Bartl, Jasmin
Mori, Takatoshi
Riederer, Peter
Ozawa, Hiroki
Grünblatt, Edna
author_facet Bartl, Jasmin
Mori, Takatoshi
Riederer, Peter
Ozawa, Hiroki
Grünblatt, Edna
author_sort Bartl, Jasmin
collection PubMed
description BACKGROUND: The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC). FINDINGS AND CONCLUSION: We found that MPH enhanced neuronal differentiation and inhibited neural proliferation.
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spelling pubmed-42240102014-11-18 Methylphenidate enhances neural stem cell differentiation Bartl, Jasmin Mori, Takatoshi Riederer, Peter Ozawa, Hiroki Grünblatt, Edna J Mol Psychiatry Short Report BACKGROUND: The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD). Since therapy often begins at a time when the brain is still developing and the long-term consequences of MPH are still not fully clarified, we examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC). FINDINGS AND CONCLUSION: We found that MPH enhanced neuronal differentiation and inhibited neural proliferation. BioMed Central 2013-04-23 /pmc/articles/PMC4224010/ /pubmed/25408898 http://dx.doi.org/10.1186/2049-9256-1-5 Text en © Bartl et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Bartl, Jasmin
Mori, Takatoshi
Riederer, Peter
Ozawa, Hiroki
Grünblatt, Edna
Methylphenidate enhances neural stem cell differentiation
title Methylphenidate enhances neural stem cell differentiation
title_full Methylphenidate enhances neural stem cell differentiation
title_fullStr Methylphenidate enhances neural stem cell differentiation
title_full_unstemmed Methylphenidate enhances neural stem cell differentiation
title_short Methylphenidate enhances neural stem cell differentiation
title_sort methylphenidate enhances neural stem cell differentiation
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224010/
https://www.ncbi.nlm.nih.gov/pubmed/25408898
http://dx.doi.org/10.1186/2049-9256-1-5
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AT ozawahiroki methylphenidateenhancesneuralstemcelldifferentiation
AT grunblattedna methylphenidateenhancesneuralstemcelldifferentiation

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