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Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

Homology-dependent exchange of genetic information between DNA molecules has a profound impact on the maintenance of genome integrity by facilitating error-free DNA repair, replication, and chromosome segregation during cell division as well as programmed cell developmental events. This chapter will...

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Detalles Bibliográficos
Autores principales: Symington, Lorraine S., Rothstein, Rodney, Lisby, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224172/
https://www.ncbi.nlm.nih.gov/pubmed/25381364
http://dx.doi.org/10.1534/genetics.114.166140
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author Symington, Lorraine S.
Rothstein, Rodney
Lisby, Michael
author_facet Symington, Lorraine S.
Rothstein, Rodney
Lisby, Michael
author_sort Symington, Lorraine S.
collection PubMed
description Homology-dependent exchange of genetic information between DNA molecules has a profound impact on the maintenance of genome integrity by facilitating error-free DNA repair, replication, and chromosome segregation during cell division as well as programmed cell developmental events. This chapter will focus on homologous mitotic recombination in budding yeast Saccharomyces cerevisiae. However, there is an important link between mitotic and meiotic recombination (covered in the forthcoming chapter by Hunter et al. 2015) and many of the functions are evolutionarily conserved. Here we will discuss several models that have been proposed to explain the mechanism of mitotic recombination, the genes and proteins involved in various pathways, the genetic and physical assays used to discover and study these genes, and the roles of many of these proteins inside the cell.
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spelling pubmed-42241722014-11-10 Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae Symington, Lorraine S. Rothstein, Rodney Lisby, Michael Genetics YeastBook Homology-dependent exchange of genetic information between DNA molecules has a profound impact on the maintenance of genome integrity by facilitating error-free DNA repair, replication, and chromosome segregation during cell division as well as programmed cell developmental events. This chapter will focus on homologous mitotic recombination in budding yeast Saccharomyces cerevisiae. However, there is an important link between mitotic and meiotic recombination (covered in the forthcoming chapter by Hunter et al. 2015) and many of the functions are evolutionarily conserved. Here we will discuss several models that have been proposed to explain the mechanism of mitotic recombination, the genes and proteins involved in various pathways, the genetic and physical assays used to discover and study these genes, and the roles of many of these proteins inside the cell. Genetics Society of America 2014-11 2014-11-01 /pmc/articles/PMC4224172/ /pubmed/25381364 http://dx.doi.org/10.1534/genetics.114.166140 Text en Copyright © 2014 by the Genetics Society of America Available freely online through the author-supported open access option.
spellingShingle YeastBook
Symington, Lorraine S.
Rothstein, Rodney
Lisby, Michael
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
title Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
title_full Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
title_fullStr Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
title_full_unstemmed Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
title_short Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
title_sort mechanisms and regulation of mitotic recombination in saccharomyces cerevisiae
topic YeastBook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224172/
https://www.ncbi.nlm.nih.gov/pubmed/25381364
http://dx.doi.org/10.1534/genetics.114.166140
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