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Interplay of the Bacterial Ribosomal A-Site, S12 Protein Mutations and Paromomycin Binding: A Molecular Dynamics Study

The conformational properties of the aminoacyl-tRNA binding site (A-site), and its surroundings in the Escherichia coli 30S ribosomal subunit, are of great relevance in designing antibacterial agents. The 30S subunit A-site is near ribosomal protein S12, which neighbors helices h27 and H69; this lat...

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Detalles Bibliográficos
Autores principales:	Panecka, Joanna, Mura, Cameron, Trylska, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224418/ https://www.ncbi.nlm.nih.gov/pubmed/25379961 http://dx.doi.org/10.1371/journal.pone.0111811

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