Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent demethylation. Recent evidence has shown that...

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Detalles Bibliográficos
Autores principales: Dong, Cheng, Zhang, Heng, Xu, Chao, Arrowsmith, Cheryl H., Min, Jinrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Feature Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224472/
https://www.ncbi.nlm.nih.gov/pubmed/25485134
http://dx.doi.org/10.1107/S2052252514020922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224472/
https://www.ncbi.nlm.nih.gov/pubmed/25485134
http://dx.doi.org/10.1107/S2052252514020922

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