One-Pot Two-Step Radiosynthesis of a New (18)F-Labeled Thiol Reactive Prosthetic Group and Its Conjugate for Insulinoma Imaging

[Image: see text] N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)-6-fluoronicotinamide ([(18)F]FNEM), a novel prosthetic agent that is thiol-specific, was synthesized using a one-pot two-step strategy: (1) (18)F incorporation by a nucleophilic displacement of trimethylammonium substrate under mild...

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Detalles Bibliográficos
Autores principales: Yue, Xuyi, Yan, Xuefeng, Wu, Chenxi, Niu, Gang, Ma, Ying, Jacobson, Orit, Shen, Baozhong, Kiesewetter, Dale O., Chen, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224565/
https://www.ncbi.nlm.nih.gov/pubmed/24798315
http://dx.doi.org/10.1021/mp5001857

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