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Adverse events: ART and the kidney: alterations in renal function and renal toxicity
Renal dysfunction is common in HIV-positive patients who receive antiretroviral therapy (ART). Several antiretrovirals have been associated with kidney disease progression, inhibition of renal tubular transporters that mediate creatinine secretion or impaired reabsorption of phosphate and low-molecu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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International AIDS Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224819/ https://www.ncbi.nlm.nih.gov/pubmed/25394022 http://dx.doi.org/10.7448/IAS.17.4.19513 |
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author | Post, Frank |
author_facet | Post, Frank |
author_sort | Post, Frank |
collection | PubMed |
description | Renal dysfunction is common in HIV-positive patients who receive antiretroviral therapy (ART). Several antiretrovirals have been associated with kidney disease progression, inhibition of renal tubular transporters that mediate creatinine secretion or impaired reabsorption of phosphate and low-molecular weight proteins. These aberrations of renal function are typically non-treatment limiting and of unclear clinical significance. By contrast, severe renal toxicity is infrequent in well-managed patents. Tenofovir-DF and atazanavir may cause acute tubular injury, tubule-interstitial nephritis or nephrolithiasis. Discontinuation of the offending drug is required to mitigate the adverse effects on kidney or bone. This presentation will discuss ART-associated changes in renal function and treatment-limiting renal toxicity in terms of incidence, risk factors, putative mechanism and provide recommendations for clinical practice. |
format | Online Article Text |
id | pubmed-4224819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International AIDS Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42248192014-11-13 Adverse events: ART and the kidney: alterations in renal function and renal toxicity Post, Frank J Int AIDS Soc Oral Presentation – Abstract O321 Renal dysfunction is common in HIV-positive patients who receive antiretroviral therapy (ART). Several antiretrovirals have been associated with kidney disease progression, inhibition of renal tubular transporters that mediate creatinine secretion or impaired reabsorption of phosphate and low-molecular weight proteins. These aberrations of renal function are typically non-treatment limiting and of unclear clinical significance. By contrast, severe renal toxicity is infrequent in well-managed patents. Tenofovir-DF and atazanavir may cause acute tubular injury, tubule-interstitial nephritis or nephrolithiasis. Discontinuation of the offending drug is required to mitigate the adverse effects on kidney or bone. This presentation will discuss ART-associated changes in renal function and treatment-limiting renal toxicity in terms of incidence, risk factors, putative mechanism and provide recommendations for clinical practice. International AIDS Society 2014-11-02 /pmc/articles/PMC4224819/ /pubmed/25394022 http://dx.doi.org/10.7448/IAS.17.4.19513 Text en © 2014 Post F; licensee International AIDS Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Oral Presentation – Abstract O321 Post, Frank Adverse events: ART and the kidney: alterations in renal function and renal toxicity |
title | Adverse events: ART and the kidney: alterations in renal function and renal toxicity |
title_full | Adverse events: ART and the kidney: alterations in renal function and renal toxicity |
title_fullStr | Adverse events: ART and the kidney: alterations in renal function and renal toxicity |
title_full_unstemmed | Adverse events: ART and the kidney: alterations in renal function and renal toxicity |
title_short | Adverse events: ART and the kidney: alterations in renal function and renal toxicity |
title_sort | adverse events: art and the kidney: alterations in renal function and renal toxicity |
topic | Oral Presentation – Abstract O321 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224819/ https://www.ncbi.nlm.nih.gov/pubmed/25394022 http://dx.doi.org/10.7448/IAS.17.4.19513 |
work_keys_str_mv | AT postfrank adverseeventsartandthekidneyalterationsinrenalfunctionandrenaltoxicity |