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Adverse events: ART and the kidney: alterations in renal function and renal toxicity

Renal dysfunction is common in HIV-positive patients who receive antiretroviral therapy (ART). Several antiretrovirals have been associated with kidney disease progression, inhibition of renal tubular transporters that mediate creatinine secretion or impaired reabsorption of phosphate and low-molecu...

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Autor principal: Post, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224819/
https://www.ncbi.nlm.nih.gov/pubmed/25394022
http://dx.doi.org/10.7448/IAS.17.4.19513
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author Post, Frank
author_facet Post, Frank
author_sort Post, Frank
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description Renal dysfunction is common in HIV-positive patients who receive antiretroviral therapy (ART). Several antiretrovirals have been associated with kidney disease progression, inhibition of renal tubular transporters that mediate creatinine secretion or impaired reabsorption of phosphate and low-molecular weight proteins. These aberrations of renal function are typically non-treatment limiting and of unclear clinical significance. By contrast, severe renal toxicity is infrequent in well-managed patents. Tenofovir-DF and atazanavir may cause acute tubular injury, tubule-interstitial nephritis or nephrolithiasis. Discontinuation of the offending drug is required to mitigate the adverse effects on kidney or bone. This presentation will discuss ART-associated changes in renal function and treatment-limiting renal toxicity in terms of incidence, risk factors, putative mechanism and provide recommendations for clinical practice.
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spelling pubmed-42248192014-11-13 Adverse events: ART and the kidney: alterations in renal function and renal toxicity Post, Frank J Int AIDS Soc Oral Presentation – Abstract O321 Renal dysfunction is common in HIV-positive patients who receive antiretroviral therapy (ART). Several antiretrovirals have been associated with kidney disease progression, inhibition of renal tubular transporters that mediate creatinine secretion or impaired reabsorption of phosphate and low-molecular weight proteins. These aberrations of renal function are typically non-treatment limiting and of unclear clinical significance. By contrast, severe renal toxicity is infrequent in well-managed patents. Tenofovir-DF and atazanavir may cause acute tubular injury, tubule-interstitial nephritis or nephrolithiasis. Discontinuation of the offending drug is required to mitigate the adverse effects on kidney or bone. This presentation will discuss ART-associated changes in renal function and treatment-limiting renal toxicity in terms of incidence, risk factors, putative mechanism and provide recommendations for clinical practice. International AIDS Society 2014-11-02 /pmc/articles/PMC4224819/ /pubmed/25394022 http://dx.doi.org/10.7448/IAS.17.4.19513 Text en © 2014 Post F; licensee International AIDS Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Oral Presentation – Abstract O321
Post, Frank
Adverse events: ART and the kidney: alterations in renal function and renal toxicity
title Adverse events: ART and the kidney: alterations in renal function and renal toxicity
title_full Adverse events: ART and the kidney: alterations in renal function and renal toxicity
title_fullStr Adverse events: ART and the kidney: alterations in renal function and renal toxicity
title_full_unstemmed Adverse events: ART and the kidney: alterations in renal function and renal toxicity
title_short Adverse events: ART and the kidney: alterations in renal function and renal toxicity
title_sort adverse events: art and the kidney: alterations in renal function and renal toxicity
topic Oral Presentation – Abstract O321
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224819/
https://www.ncbi.nlm.nih.gov/pubmed/25394022
http://dx.doi.org/10.7448/IAS.17.4.19513
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