Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism

The excitatory amino acid transporters (EAATs) are transmembrane proteins responsible for the uptake of (S)-glutamate from the synaptic cleft. To date, five subtypes EAAT1-5 have been identified for which selective inhibitors have been discovered for EAAT1 and EAAT2. By screening of a commercially a...

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Detalles Bibliográficos
Autores principales: Huynh, Tri HV, Demmer, Charles S, Abrahamsen, Bjarke, Marcher, Emil, Frykman, Mikael, Jensen, Anders A, Bunch, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225009/
https://www.ncbi.nlm.nih.gov/pubmed/25530930
http://dx.doi.org/10.1186/2193-1801-2-112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225009/
https://www.ncbi.nlm.nih.gov/pubmed/25530930
http://dx.doi.org/10.1186/2193-1801-2-112

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