Age-dependent increase in miRNA-34a expression in the posterior pole of the mouse eye

PURPOSE: MicroRNA-34a (miR-34a) has been implicated in neurodegeneration. MiR-34a belongs to a signaling network involving p53 and Sirt-1. This network responds to DNA damage with further downstream signals that induce senescence or apoptosis. Our goal was to measure the expression level of miR-34a...

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Detalles Bibliográficos
Autores principales: Smit-McBride, Zeljka, Forward, Krisztina I., Nguyen, Anthony T., Bordbari, Matthew H., Oltjen, Sharon L., Hjelmeland, Leonard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225137/
https://www.ncbi.nlm.nih.gov/pubmed/25489229

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