HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M

INTRODUCTION: HIV-1 group O (HIV-O) is a rare HIV-1 variant characterized by a high number of polymorphisms, especially in the integrase gene, e.g. positions L74I, S153A, G163Q and T206S. As HIV-O integrase enzymes have not previously been studied, our aim was to assess the impact of HIV-O integrase...

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Detalles Bibliográficos
Autores principales: Depatureaux, Agnès, Mesplède, Thibault, Quashie, Peter, Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma, Wainberg, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Poster Sessions – Abstract P206
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225329/
https://www.ncbi.nlm.nih.gov/pubmed/25397483
http://dx.doi.org/10.7448/IAS.17.4.19738

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