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Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest

INTRODUCTION: After the 2008 introduction of new psychoactive substances (NPS) in Romania, the number of newly diagnosed HIV infections showed significant increase among injecting drug users (IDUs). Our objective was to analyze the differences between co-infections related to the HIV infection, base...

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Autores principales: Manea, Eliza, Jipa, Raluca, Niculescu, Iulia, Benea, Serban, Benea, Otilia, Arama, Victoria, Hristea, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225450/
https://www.ncbi.nlm.nih.gov/pubmed/25397415
http://dx.doi.org/10.7448/IAS.17.4.19665
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author Manea, Eliza
Jipa, Raluca
Niculescu, Iulia
Benea, Serban
Benea, Otilia
Arama, Victoria
Hristea, Adriana
author_facet Manea, Eliza
Jipa, Raluca
Niculescu, Iulia
Benea, Serban
Benea, Otilia
Arama, Victoria
Hristea, Adriana
author_sort Manea, Eliza
collection PubMed
description INTRODUCTION: After the 2008 introduction of new psychoactive substances (NPS) in Romania, the number of newly diagnosed HIV infections showed significant increase among injecting drug users (IDUs). Our objective was to analyze the differences between co-infections related to the HIV infection, based on the way of transmission (IDUs versus sexually infected). MATERIALS AND METHODS: A retrospective transversal study was carried out, analyzing 245 adult HIV-positive patients, diagnosed between January 2013 and December 2013 in our hospital. We collected socio-demographic, epidemiological and laboratory data at the diagnosis and analyzed them using SPSS version 20. RESULTS: Most patients (71%, 174/245) were men and the median age was 32 years (IQR: 26–38). 91 patients (37%) were former/active IDUs (most of them injecting both opioids and NPS), while 154 patients (63%) were sexually infected, with 84% being heterosexuals and 16% men having sex with men (MSM). The median CD4 count, at the moment of diagnosis, was 294 cells/mm(3) (IQR: 119–483). Other co-infections at diagnosis were toxoplasmosis (four patients), cryptococcosis (two patients) and cytomegalovirus reactivations (three patients) without significant association between the two groups. CONCLUSION: Heterosexual transmission was the most common way of HIV transmission in 2013 in contrast with EU/CEE, where MSM accounted for the majority of cases of HIV epidemics in 2012 [1]. Sexually transmitted HIV infection was associated with late presentation, stage C and syphilis. We noted a high percentage of IDU transmission, which was associated with stage A and hepatitis C infection.
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spelling pubmed-42254502014-11-12 Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest Manea, Eliza Jipa, Raluca Niculescu, Iulia Benea, Serban Benea, Otilia Arama, Victoria Hristea, Adriana J Int AIDS Soc Poster Sessions – Abstract P133 INTRODUCTION: After the 2008 introduction of new psychoactive substances (NPS) in Romania, the number of newly diagnosed HIV infections showed significant increase among injecting drug users (IDUs). Our objective was to analyze the differences between co-infections related to the HIV infection, based on the way of transmission (IDUs versus sexually infected). MATERIALS AND METHODS: A retrospective transversal study was carried out, analyzing 245 adult HIV-positive patients, diagnosed between January 2013 and December 2013 in our hospital. We collected socio-demographic, epidemiological and laboratory data at the diagnosis and analyzed them using SPSS version 20. RESULTS: Most patients (71%, 174/245) were men and the median age was 32 years (IQR: 26–38). 91 patients (37%) were former/active IDUs (most of them injecting both opioids and NPS), while 154 patients (63%) were sexually infected, with 84% being heterosexuals and 16% men having sex with men (MSM). The median CD4 count, at the moment of diagnosis, was 294 cells/mm(3) (IQR: 119–483). Other co-infections at diagnosis were toxoplasmosis (four patients), cryptococcosis (two patients) and cytomegalovirus reactivations (three patients) without significant association between the two groups. CONCLUSION: Heterosexual transmission was the most common way of HIV transmission in 2013 in contrast with EU/CEE, where MSM accounted for the majority of cases of HIV epidemics in 2012 [1]. Sexually transmitted HIV infection was associated with late presentation, stage C and syphilis. We noted a high percentage of IDU transmission, which was associated with stage A and hepatitis C infection. International AIDS Society 2014-11-02 /pmc/articles/PMC4225450/ /pubmed/25397415 http://dx.doi.org/10.7448/IAS.17.4.19665 Text en © 2014 Manea E et al; licensee International AIDS Society http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Poster Sessions – Abstract P133
Manea, Eliza
Jipa, Raluca
Niculescu, Iulia
Benea, Serban
Benea, Otilia
Arama, Victoria
Hristea, Adriana
Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest
title Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest
title_full Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest
title_fullStr Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest
title_full_unstemmed Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest
title_short Co-infections and co-morbidities among injecting drug users versus sexually infected patients in Bucharest
title_sort co-infections and co-morbidities among injecting drug users versus sexually infected patients in bucharest
topic Poster Sessions – Abstract P133
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225450/
https://www.ncbi.nlm.nih.gov/pubmed/25397415
http://dx.doi.org/10.7448/IAS.17.4.19665
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