Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects

Blocking the CD40–CD154 interaction is reported to be effective for transplantation management and autoimmune disease models in rodents and nonhuman primates. However, clinical trials with anti-CD154 mAbs were halted because of high incidence of thromboembolic complications. Thus, we generated and c...

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Detalles Bibliográficos
Autores principales: Okimura, K, Maeta, K, Kobayashi, N, Goto, M, Kano, N, Ishihara, T, Ishikawa, T, Tsumura, H, Ueno, A, Miyao, Y, Sakuma, S, Kinugasa, F, Takahashi, N, Miura, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225473/
https://www.ncbi.nlm.nih.gov/pubmed/24731050
http://dx.doi.org/10.1111/ajt.12678

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