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Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1

BACKGROUND: Spinocerebellar ataxia type 1 (SCA1) is a genetic disorder characterized by severe ataxia associated with progressive loss of cerebellar Purkinje cells. The mGlu1 metabotropic glutamate receptor plays a key role in mechanisms of activity-dependent synaptic plasticity in the cerebellum, a...

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Detalles Bibliográficos
Autores principales:	Notartomaso, Serena, Zappulla, Cristina, Biagioni, Francesca, Cannella, Milena, Bucci, Domenico, Mascio, Giada, Scarselli, Pamela, Fazio, Francesco, Weisz, Filippo, Lionetto, Luana, Simmaco, Maurizio, Gradini, Roberto, Battaglia, Giuseppe, Signore, Michele, Puliti, Aldamaria, Nicoletti, Ferdinando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225515/ https://www.ncbi.nlm.nih.gov/pubmed/24252411 http://dx.doi.org/10.1186/1756-6606-6-48

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