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Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys

OBJECTIVES: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid...

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Autores principales: Choi, Young Sim, Jang, Han Byul, Park, Ju Yeon, Lee, Hye-Ja, Kang, Jae-Heon, Park, Kyung-Hee, Lee, Jong Ho, Park, Sang Ick, Song, Jihyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225645/
https://www.ncbi.nlm.nih.gov/pubmed/25389510
http://dx.doi.org/10.1016/j.phrp.2014.08.008
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author Choi, Young Sim
Jang, Han Byul
Park, Ju Yeon
Lee, Hye-Ja
Kang, Jae-Heon
Park, Kyung-Hee
Lee, Jong Ho
Park, Sang Ick
Song, Jihyun
author_facet Choi, Young Sim
Jang, Han Byul
Park, Ju Yeon
Lee, Hye-Ja
Kang, Jae-Heon
Park, Kyung-Hee
Lee, Jong Ho
Park, Sang Ick
Song, Jihyun
author_sort Choi, Young Sim
collection PubMed
description OBJECTIVES: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders. METHODS: Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85(th) percentile for age and gender, based on Korean child growth standards. RESULTS: Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up. CONCLUSION: In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.
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spelling pubmed-42256452014-11-11 Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys Choi, Young Sim Jang, Han Byul Park, Ju Yeon Lee, Hye-Ja Kang, Jae-Heon Park, Kyung-Hee Lee, Jong Ho Park, Sang Ick Song, Jihyun Osong Public Health Res Perspect Original Article OBJECTIVES: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders. METHODS: Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85(th) percentile for age and gender, based on Korean child growth standards. RESULTS: Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up. CONCLUSION: In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia. 2014-09-04 2014-10 /pmc/articles/PMC4225645/ /pubmed/25389510 http://dx.doi.org/10.1016/j.phrp.2014.08.008 Text en © 2014 Published by Elsevier B.V. on behalf of Korea Centers for Disease Control and Prevention. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
spellingShingle Original Article
Choi, Young Sim
Jang, Han Byul
Park, Ju Yeon
Lee, Hye-Ja
Kang, Jae-Heon
Park, Kyung-Hee
Lee, Jong Ho
Park, Sang Ick
Song, Jihyun
Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
title Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
title_full Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
title_fullStr Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
title_full_unstemmed Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
title_short Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
title_sort associations between estimated desaturase activity and insulin resistance in korean boys
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225645/
https://www.ncbi.nlm.nih.gov/pubmed/25389510
http://dx.doi.org/10.1016/j.phrp.2014.08.008
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