Hypoplastic Left Heart Syndrome – Unresolved Issues

Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present, it is expected that – at best – 70% of newborns with HLHS will reach adulthood. This review addresses the problems of right ventricular (RV) failure and insufficient growth of pulmonary vascul...

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Autores principales: Arnold, Raoul Roman, Loukanov, Tsvetomir, Gorenflo, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225740/
https://www.ncbi.nlm.nih.gov/pubmed/25426478
http://dx.doi.org/10.3389/fped.2014.00125
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author Arnold, Raoul Roman
Loukanov, Tsvetomir
Gorenflo, Matthias
author_facet Arnold, Raoul Roman
Loukanov, Tsvetomir
Gorenflo, Matthias
author_sort Arnold, Raoul Roman
collection PubMed
description Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present, it is expected that – at best – 70% of newborns with HLHS will reach adulthood. This review addresses the problems of right ventricular (RV) failure and insufficient growth of pulmonary vasculature in these patients. In order to further improve long-term prognosis translational research to control RV function, growth of pulmonary arteries and progress in chronic circulatory support are clearly needed to provide a further improvement for adults with HLHS.
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spelling pubmed-42257402014-11-25 Hypoplastic Left Heart Syndrome – Unresolved Issues Arnold, Raoul Roman Loukanov, Tsvetomir Gorenflo, Matthias Front Pediatr Pediatrics Hypoplastic left heart syndrome (HLHS) is one of the most challenging congenital heart defects. At present, it is expected that – at best – 70% of newborns with HLHS will reach adulthood. This review addresses the problems of right ventricular (RV) failure and insufficient growth of pulmonary vasculature in these patients. In order to further improve long-term prognosis translational research to control RV function, growth of pulmonary arteries and progress in chronic circulatory support are clearly needed to provide a further improvement for adults with HLHS. Frontiers Media S.A. 2014-11-10 /pmc/articles/PMC4225740/ /pubmed/25426478 http://dx.doi.org/10.3389/fped.2014.00125 Text en Copyright © 2014 Arnold, Loukanov and Gorenflo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Arnold, Raoul Roman
Loukanov, Tsvetomir
Gorenflo, Matthias
Hypoplastic Left Heart Syndrome – Unresolved Issues
title Hypoplastic Left Heart Syndrome – Unresolved Issues
title_full Hypoplastic Left Heart Syndrome – Unresolved Issues
title_fullStr Hypoplastic Left Heart Syndrome – Unresolved Issues
title_full_unstemmed Hypoplastic Left Heart Syndrome – Unresolved Issues
title_short Hypoplastic Left Heart Syndrome – Unresolved Issues
title_sort hypoplastic left heart syndrome – unresolved issues
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225740/
https://www.ncbi.nlm.nih.gov/pubmed/25426478
http://dx.doi.org/10.3389/fped.2014.00125
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