The Arctic AβPP mutation leads to Alzheimer’s disease pathology with highly variable topographic deposition of differentially truncated Aβ

BACKGROUND: The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here we report the special character of Arctic AD neuropathology in four deceased pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalimo, Hannu, Lalowski, Maciej, Bogdanovic, Nenad, Philipson, Ola, Bird, Thomas D, Nochlin, David, Schellenberg, Gerard D, Brundin, RoseMarie, Olofsson, Tommie, Soliymani, Rabah, Baumann, Marc, Wirths, Oliver, Bayer, Thomas A, Nilsson, Lars NG, Basun, Hans, Lannfelt, Lars, Ingelsson, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226306/
https://www.ncbi.nlm.nih.gov/pubmed/24252272
http://dx.doi.org/10.1186/2051-5960-1-60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226306/
https://www.ncbi.nlm.nih.gov/pubmed/24252272
http://dx.doi.org/10.1186/2051-5960-1-60

Ejemplares similares