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TCR Triggering by pMHC Ligands Tethered on Surfaces via Poly(Ethylene Glycol) Depends on Polymer Length
Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that both the ligand and receptor...
Autores principales: | Ma, Zhengyu, LeBard, David N., Loverde, Sharon M., Sharp, Kim A., Klein, Michael L., Discher, Dennis E., Finkel, Terri H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226474/ https://www.ncbi.nlm.nih.gov/pubmed/25383949 http://dx.doi.org/10.1371/journal.pone.0112292 |
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