A Physiologically-Motivated Compartment-Based Model of the Effect of Inhaled Hypertonic Saline on Mucociliary Clearance and Liquid Transport in Cystic Fibrosis

BACKGROUND: Cystic Fibrosis (CF) lung disease is characterized by liquid hyperabsorption, airway surface dehydration, and impaired mucociliary clearance (MCC). Herein, we present a compartment-based mathematical model of the airway that extends the resolution of functional imaging data. METHODS: Usi...

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Detalles Bibliográficos
Autores principales: Markovetz, Matthew R., Corcoran, Timothy E., Locke, Landon W., Myerburg, Michael M., Pilewski, Joseph M., Parker, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226497/
https://www.ncbi.nlm.nih.gov/pubmed/25383714
http://dx.doi.org/10.1371/journal.pone.0111972

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