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A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer
We investigated the application of a mimetic 20 amino acid peptide derived from type IV collagen for treatment of breast cancer. We showed that the peptide induced a decrease of proliferation, adhesion, and migration of endothelial and tumor cells in vitro. We also observed an inhibition of triple n...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226498/ https://www.ncbi.nlm.nih.gov/pubmed/25384034 http://dx.doi.org/10.1371/journal.pone.0111901 |
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author | Rosca, Elena V. Penet, Marie-France Mori, Noriko Koskimaki, Jacob E. Lee, Esak Pandey, Niranjan B. Bhujwalla, Zaver M. Popel, Aleksander S. |
author_facet | Rosca, Elena V. Penet, Marie-France Mori, Noriko Koskimaki, Jacob E. Lee, Esak Pandey, Niranjan B. Bhujwalla, Zaver M. Popel, Aleksander S. |
author_sort | Rosca, Elena V. |
collection | PubMed |
description | We investigated the application of a mimetic 20 amino acid peptide derived from type IV collagen for treatment of breast cancer. We showed that the peptide induced a decrease of proliferation, adhesion, and migration of endothelial and tumor cells in vitro. We also observed an inhibition of triple negative MDA-MB-231 xenograft growth by 75% relative to control when administered intraperitoneally for 27 days at 10 mg/kg. We monitored in vivo the changes in vascular properties throughout the treatment using MRI and found that the vascular volume and permeability surface area product decreased significantly. The treatment also resulted in an increase of caspase-3 activity and in a reduction of microvascular density. The multiple mode of action of this peptide, i.e., anti-angiogenic, and anti-tumorigenic, makes it a viable candidate as a therapeutic agent as a monotherapy or in combination with other compounds. |
format | Online Article Text |
id | pubmed-4226498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42264982014-11-13 A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer Rosca, Elena V. Penet, Marie-France Mori, Noriko Koskimaki, Jacob E. Lee, Esak Pandey, Niranjan B. Bhujwalla, Zaver M. Popel, Aleksander S. PLoS One Research Article We investigated the application of a mimetic 20 amino acid peptide derived from type IV collagen for treatment of breast cancer. We showed that the peptide induced a decrease of proliferation, adhesion, and migration of endothelial and tumor cells in vitro. We also observed an inhibition of triple negative MDA-MB-231 xenograft growth by 75% relative to control when administered intraperitoneally for 27 days at 10 mg/kg. We monitored in vivo the changes in vascular properties throughout the treatment using MRI and found that the vascular volume and permeability surface area product decreased significantly. The treatment also resulted in an increase of caspase-3 activity and in a reduction of microvascular density. The multiple mode of action of this peptide, i.e., anti-angiogenic, and anti-tumorigenic, makes it a viable candidate as a therapeutic agent as a monotherapy or in combination with other compounds. Public Library of Science 2014-11-10 /pmc/articles/PMC4226498/ /pubmed/25384034 http://dx.doi.org/10.1371/journal.pone.0111901 Text en © 2014 Rosca et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Rosca, Elena V. Penet, Marie-France Mori, Noriko Koskimaki, Jacob E. Lee, Esak Pandey, Niranjan B. Bhujwalla, Zaver M. Popel, Aleksander S. A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer |
title | A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer |
title_full | A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer |
title_fullStr | A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer |
title_full_unstemmed | A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer |
title_short | A Biomimetic Collagen Derived Peptide Exhibits Anti-Angiogenic Activity in Triple Negative Breast Cancer |
title_sort | biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226498/ https://www.ncbi.nlm.nih.gov/pubmed/25384034 http://dx.doi.org/10.1371/journal.pone.0111901 |
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