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Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis

Celastrol, a tripterine derived from the traditional Chinese medicine plant Tripterygium wilfordii Hook F. (“Thunder of God Vine”), has been reported to have multiple effects, such as anti-inflammation, suppression of tumor angiogenesis, inhibition of tumor growth, induction of apoptosis and protect...

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Detalles Bibliográficos
Autores principales:	Han, Xiaoxi, Sun, Shengkun, Zhao, Ming, Cheng, Xiang, Chen, Guozhu, Lin, Song, Guan, Yifu, Yu, Xiaodan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226555/ https://www.ncbi.nlm.nih.gov/pubmed/25383959 http://dx.doi.org/10.1371/journal.pone.0112470

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