Deletion of Apoptosis Signal-Regulating Kinase 1 (ASK1) Protects Pancreatic Beta-Cells from Stress-Induced Death but Not from Glucose Homeostasis Alterations under Pro-Inflammatory Conditions

BACKGROUND: Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that apoptosis signal-regulating kinase 1 (ASK1) is involved in beta-cell death in response to different stressors. In this study, we tested whe...

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Detalles Bibliográficos
Autores principales: Pepin, Emilie, Higa, Arisa, Schuster-Klein, Carole, Bernard, Catherine, Sulpice, Thierry, Guardiola, Beatrice, Chevet, Eric, Alquier, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226582/
https://www.ncbi.nlm.nih.gov/pubmed/25383781
http://dx.doi.org/10.1371/journal.pone.0112714

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