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Lung injury after simulated cardiopulmonary bypass in an isolated perfused rat lung preparation: Role of mitogen-activated protein kinase/Akt signaling and the effects of theophylline

OBJECTIVES: Lung deflation and inflation during cardiac surgery with cardiopulmonary bypass contributes to pulmonary dysfunction postoperatively. Theophylline treatment for lung diseases has traditionally been thought to act by phosphodiesterase inhibition; however, increasing evidence has suggested...

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Detalles Bibliográficos
Autores principales: Markou, Thomais, Chambers, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226635/
https://www.ncbi.nlm.nih.gov/pubmed/24841445
http://dx.doi.org/10.1016/j.jtcvs.2014.04.037