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Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

The ubiquitin proteasome system (UPS) plays a role in the regulation of most cellular pathways, and its deregulation has been implicated in a wide range of human pathologies that include cancer, neurodegenerative and immunological disorders and viral infections. Targeting the UPS by small molecular...

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Detalles Bibliográficos
Autores principales:	Landré, Vivien, Rotblat, Barak, Melino, Sonia, Bernassola, Francesca, Melino, Gerry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226663/ https://www.ncbi.nlm.nih.gov/pubmed/25237759

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