TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity

p53 plays a key role in regulating DNA damage response by suppressing cell cycle progression or inducing apoptosis depending on extent of DNA damage. However, it is not clear why mild genotoxic stress favors growth arrest, whereas excessive lesions signal cells to die. Here we showed that TAp73, a p...

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Detalles Bibliográficos
Autores principales: Chen, Dongshi, Ming, Lihua, Zou, Fangdong, Peng, Ye, Houten, Bennett Van, Yu, Jian, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226670/
https://www.ncbi.nlm.nih.gov/pubmed/25237903

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