Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

Alterations in the signaling pathways of epidermal growth factor receptors (HERs) are associated with tumor aggressiveness. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 60% of lung cancers. In a previous clinical study, NTSR1 overexpression was shown to predict a poor...

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Detalles Bibliográficos
Autores principales: Younes, Mohamad, Wu, Zherui, Dupouy, Sandra, Lupo, Audrey Mansuet, Mourra, Najat, Takahashi, Takashi, Fléjou, Jean François, Trédaniel, Jean, Régnard, Jean François, Damotte, Diane, Alifano, Marco, Forgez, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226681/
https://www.ncbi.nlm.nih.gov/pubmed/25249545

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