Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth. We examined the anti-CSC effects of the antifungal polyketide soraphen A, a specific inhibitor of the first committed st...

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Detalles Bibliográficos
Autores principales: Corominas-Faja, Bruna, Cuyàs, Elisabet, Gumuzio, Juan, Bosch-Barrera, Joaquim, Leis, Olatz, Martin, Ángel G., Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226684/
https://www.ncbi.nlm.nih.gov/pubmed/25246709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226684/
https://www.ncbi.nlm.nih.gov/pubmed/25246709

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