Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism

Picropodophyllin (PPP) is an anticancer drug undergoing clinical development in NSCLC. PPP has been shown to suppress IGF-1R signaling and to induce a G2/M cell cycle phase arrest but the exact mechanisms remain to be elucidated. The present study identified an IGF-1-independent mechanism of PPP lea...

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Detalles Bibliográficos
Autores principales: Waraky, Ahmed, Akopyan, Karen, Parrow, Vendela, Strömberg, Thomas, Axelson, Magnus, Abrahmsén, Lars, Lindqvist, Arne, Larsson, Olle, Aleem, Eiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226690/
https://www.ncbi.nlm.nih.gov/pubmed/25268741

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