Cargando…

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

The mTOR pathway controls mRNA translation of mitogenic proteins and is a central regulator of metabolism in malignant cells. Development of malignant cell resistance is a limiting factor to the effects of mTOR inhibitors, but the mechanisms accounting for such resistance are not well understood. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eckerdt, Frank, Beauchamp, Elspeth, Bell, Jonathan, Iqbal, Asneha, Su, Bing, Fukunaga, Rikiro, Lulla, Rishi R., Goldman, Stewart, Platanias, Leonidas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226695/ https://www.ncbi.nlm.nih.gov/pubmed/25193863

Ejemplares similares

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

Circadian activities of the brain MNK‐eIF4E signalling axis contribute to diurnal rhythms of some cognitive functions
por: Liu, Dong, et al.
Publicado: (2022)

Pharmacological mTOR targeting enhances the antineoplastic effects of selective PI3Kα inhibition in medulloblastoma
por: Eckerdt, Frank, et al.
Publicado: (2019)

Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
por: Iqbal, Asneha, et al.
Publicado: (2016)

MNK Proteins as Therapeutic Targets in Leukemia
por: Mazewski, Candice, et al.
Publicado: (2023)

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma
por: Bell, Jonathan B., et al.
Publicado: (2018)

The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma
por: Prabhu, Sathyen A., et al.
Publicado: (2020)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling
por: Shen, Peng, et al.
Publicado: (2018)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
por: Gandin, Valentina, et al.
Publicado: (2016)

Phosphorylated Mnk1 and eIF4E Are Associated with Lymph Node Metastasis and Poor Prognosis of Nasopharyngeal Carcinoma
por: Zheng, Jun, et al.
Publicado: (2014)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling
por: Martin, Pauline, et al.
Publicado: (2020)

Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy
por: Li, Zhiqiang, et al.
Publicado: (2016)

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
por: Klann, Kevin, et al.
Publicado: (2020)

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity
por: Crombie, Elisa M., et al.
Publicado: (2022)

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)
por: Rios-Fuller, Tiffany J., et al.
Publicado: (2020)

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
por: Yi, Woelsung, et al.
Publicado: (2017)

Infection by the Protozoan Parasite Toxoplasma gondii Inhibits Host MNK1/2-eIF4E Axis to Promote Its Survival
por: Leroux, Louis-Philippe, et al.
Publicado: (2020)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
por: Wang, Zeng, et al.
Publicado: (2020)

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1
por: Morris, Christelle, et al.
Publicado: (2021)

The mTORC1/eIF4E/HIF-1α Pathway Mediates Glycolysis to Support Brain Hypoxia Resistance in the Gansu Zokor, Eospalax cansus
por: Lin, Jinyan, et al.
Publicado: (2021)

Simultaneous Inhibition of mTOR-Containing Complex 1 (mTORC1) and MNK Induces Apoptosis of Cutaneous T-Cell Lymphoma (CTCL) Cells
por: Marzec, Michal, et al.
Publicado: (2011)

Emerging Role of Glioma Stem Cells in Mechanisms of Therapy Resistance
por: Eckerdt, Frank, et al.
Publicado: (2023)

Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia
por: Shi, Fangfang, et al.
Publicado: (2015)

TFEB-mTORC1 feedback loop in metabolism and cancer
por: Di Malta, Chiara, et al.
Publicado: (2017)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway: Erratum
por: Wang, Zeng, et al.
Publicado: (2022)

Retraction: Simultaneous Inhibition of mTOR-Containing Complex 1 (mTORC1) and MNK Induces Apoptosis of Cutaneous T-Cell Lymphoma (CTCL) Cells
Publicado: (2020)

Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells
por: Lineham, Ella, et al.
Publicado: (2018)

Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming
por: Geter, Phillip A., et al.
Publicado: (2017)

mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells
por: Jossé, Lyne, et al.
Publicado: (2016)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

eIF4A inactivates TORC1 in response to amino acid starvation
por: Tsokanos, Foivos‐Filippos, et al.
Publicado: (2016)

mTORc1 activity is necessary and sufficient for phosphorylation of eNOS(S1177)
por: Decker, Brandee, et al.
Publicado: (2018)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses
por: Shi, Yijiang, et al.
Publicado: (2014)

Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice
por: Kwegyir-Afful, Andrew K., et al.
Publicado: (2016)

Impact of eIF4E phosphorylation at Ser209 via MNK2a on tumour recurrence after curative surgery in localized clear cell renal cell carcinoma
por: Ichiyanagi, Osamu, et al.
Publicado: (2019)

Retraction: MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses
Publicado: (2023)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kin7qnku89pv5g68sgr6rit3i7