Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

Although the p53 tumor suppressor/transcription factor often accumulates in the cytoplasm of healthy cells, limited information is available on the cytoplasmic function of p53. Here, we show that cytoplasmic p53 suppresses cell invasion by reducing mitochondrial reactive oxygen species (ROS) levels....

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Detalles Bibliográficos
Autores principales: Kim, Eun Mi, Park, Jong Kuk, Hwang, Sang-Gu, Kim, Wun-Jae, Liu, Zheng-Gang, Kang, Sang Won, Um, Hong-Duck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226696/
https://www.ncbi.nlm.nih.gov/pubmed/25115399

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