The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

Here we showed that hepatocellular carcinoma (HCC) cell lines with high metastatic potential had low levels of NDRG2. The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having high metastatic potential. Also Dp44mT at...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jiabei, Yin, Dalong, Xie, Changming, Zheng, Tongsen, Liang, Yingjian, Hong, Xuehui, Lu, Zhaoyang, Song, Xuan, Song, Ruipeng, Yang, Haiyan, Sun, Boshi, Bhatta, Nishant, Meng, Xianzhi, Pan, Shangha, Jiang, Hongchi, Liu, Lianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226698/
https://www.ncbi.nlm.nih.gov/pubmed/25261367
_version_ 1782343663298281472
author Wang, Jiabei
Yin, Dalong
Xie, Changming
Zheng, Tongsen
Liang, Yingjian
Hong, Xuehui
Lu, Zhaoyang
Song, Xuan
Song, Ruipeng
Yang, Haiyan
Sun, Boshi
Bhatta, Nishant
Meng, Xianzhi
Pan, Shangha
Jiang, Hongchi
Liu, Lianxin
author_facet Wang, Jiabei
Yin, Dalong
Xie, Changming
Zheng, Tongsen
Liang, Yingjian
Hong, Xuehui
Lu, Zhaoyang
Song, Xuan
Song, Ruipeng
Yang, Haiyan
Sun, Boshi
Bhatta, Nishant
Meng, Xianzhi
Pan, Shangha
Jiang, Hongchi
Liu, Lianxin
author_sort Wang, Jiabei
collection PubMed
description Here we showed that hepatocellular carcinoma (HCC) cell lines with high metastatic potential had low levels of NDRG2. The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having high metastatic potential. Also Dp44mT attenuated the TGF-β1-induced EMT in HCC having low metastatic potential. In agreement, silencing endogenous NDRG2 with shNDRG2 in HCC cells attenuated the effect of Dp44mT. We showed that the NDRG2/gp130/STAT3 pathway can mediate Dp44mT effects. In agreement, we found that a combination of NDRG2 expression and p-STAT3 levels is a strong predictor of prognosis in HCC patients. We suggest that up-regulation of NDRG2 by Dp44mT is a promising therapeutic approach in HCC.
format Online
Article
Text
id pubmed-4226698
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-42266982014-11-17 The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway Wang, Jiabei Yin, Dalong Xie, Changming Zheng, Tongsen Liang, Yingjian Hong, Xuehui Lu, Zhaoyang Song, Xuan Song, Ruipeng Yang, Haiyan Sun, Boshi Bhatta, Nishant Meng, Xianzhi Pan, Shangha Jiang, Hongchi Liu, Lianxin Oncotarget Research Paper Here we showed that hepatocellular carcinoma (HCC) cell lines with high metastatic potential had low levels of NDRG2. The iron chelator Dp44mT up-regulated NDRG2, suppressed epithelial-mesenchymal transition (EMT) and inhibited tumor metastasis in HCC having high metastatic potential. Also Dp44mT attenuated the TGF-β1-induced EMT in HCC having low metastatic potential. In agreement, silencing endogenous NDRG2 with shNDRG2 in HCC cells attenuated the effect of Dp44mT. We showed that the NDRG2/gp130/STAT3 pathway can mediate Dp44mT effects. In agreement, we found that a combination of NDRG2 expression and p-STAT3 levels is a strong predictor of prognosis in HCC patients. We suggest that up-regulation of NDRG2 by Dp44mT is a promising therapeutic approach in HCC. Impact Journals LLC 2014-08-08 /pmc/articles/PMC4226698/ /pubmed/25261367 Text en Copyright: © 2014 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Jiabei
Yin, Dalong
Xie, Changming
Zheng, Tongsen
Liang, Yingjian
Hong, Xuehui
Lu, Zhaoyang
Song, Xuan
Song, Ruipeng
Yang, Haiyan
Sun, Boshi
Bhatta, Nishant
Meng, Xianzhi
Pan, Shangha
Jiang, Hongchi
Liu, Lianxin
The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
title The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
title_full The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
title_fullStr The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
title_full_unstemmed The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
title_short The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
title_sort iron chelator dp44mt inhibits hepatocellular carcinoma metastasis via n-myc downstream-regulated gene 2 (ndrg2)/gp130/stat3 pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226698/
https://www.ncbi.nlm.nih.gov/pubmed/25261367
work_keys_str_mv AT wangjiabei theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT yindalong theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT xiechangming theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT zhengtongsen theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT liangyingjian theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT hongxuehui theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT luzhaoyang theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT songxuan theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT songruipeng theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT yanghaiyan theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT sunboshi theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT bhattanishant theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT mengxianzhi theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT panshangha theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT jianghongchi theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT liulianxin theironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT wangjiabei ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT yindalong ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT xiechangming ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT zhengtongsen ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT liangyingjian ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT hongxuehui ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT luzhaoyang ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT songxuan ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT songruipeng ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT yanghaiyan ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT sunboshi ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT bhattanishant ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT mengxianzhi ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT panshangha ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT jianghongchi ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway
AT liulianxin ironchelatordp44mtinhibitshepatocellularcarcinomametastasisvianmycdownstreamregulatedgene2ndrg2gp130stat3pathway

Ejemplares similares