Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells

Obscurins are RhoGEF-containing proteins whose downregulation has been implicated in the development and progression of breast cancer. Herein, we aim to elucidate the mechanism for increased motility of obscurin-deficient cells. We show that shRNA-mediated obscurin downregulation in MCF10A cells lea...

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Detalles Bibliográficos
Autores principales: Perry, Nicole A., Vitolo, Michele I., Martin, Stuart S., Kontrogianni-Konstantopoulos, Aikaterini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226704/
https://www.ncbi.nlm.nih.gov/pubmed/25261370

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