Cargando…

Bcl-6 directly represses the gene program of the glycolysis pathway

Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription fac...

Descripción completa

Detalles Bibliográficos
Autores principales: Oestreich, Kenneth J., Read, Kaitlin A., Gilbertson, Sarah E., Hough, Kenneth P., McDonald, Paul W., Krishnamoorthy, Veena, Weinmann, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226759/
https://www.ncbi.nlm.nih.gov/pubmed/25194422
http://dx.doi.org/10.1038/ni.2985
_version_ 1782343673069961216
author Oestreich, Kenneth J.
Read, Kaitlin A.
Gilbertson, Sarah E.
Hough, Kenneth P.
McDonald, Paul W.
Krishnamoorthy, Veena
Weinmann, Amy S.
author_facet Oestreich, Kenneth J.
Read, Kaitlin A.
Gilbertson, Sarah E.
Hough, Kenneth P.
McDonald, Paul W.
Krishnamoorthy, Veena
Weinmann, Amy S.
author_sort Oestreich, Kenneth J.
collection PubMed
description Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription factor Bcl-6 directly repressed genes involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm2 and Hk2, in T(H)1 cells exposed to low amounts of interleukin 2 (IL-2). Thus, Bcl-6 plays an opposing role to the IL-2-sensitive glycolytic transcriptional program that c-Myc and HIF-1α promote in effector T cells. Additionally, the Th1-lineage-specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes in the glycolysis pathway, implicating the molecular balance between these two factors in metabolic gene program regulation.
format Online
Article
Text
id pubmed-4226759
institution National Center for Biotechnology Information
language English
publishDate 2014
record_format MEDLINE/PubMed
spelling pubmed-42267592015-04-01 Bcl-6 directly represses the gene program of the glycolysis pathway Oestreich, Kenneth J. Read, Kaitlin A. Gilbertson, Sarah E. Hough, Kenneth P. McDonald, Paul W. Krishnamoorthy, Veena Weinmann, Amy S. Nat Immunol Article Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription factor Bcl-6 directly repressed genes involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm2 and Hk2, in T(H)1 cells exposed to low amounts of interleukin 2 (IL-2). Thus, Bcl-6 plays an opposing role to the IL-2-sensitive glycolytic transcriptional program that c-Myc and HIF-1α promote in effector T cells. Additionally, the Th1-lineage-specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes in the glycolysis pathway, implicating the molecular balance between these two factors in metabolic gene program regulation. 2014-09-07 2014-10 /pmc/articles/PMC4226759/ /pubmed/25194422 http://dx.doi.org/10.1038/ni.2985 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Oestreich, Kenneth J.
Read, Kaitlin A.
Gilbertson, Sarah E.
Hough, Kenneth P.
McDonald, Paul W.
Krishnamoorthy, Veena
Weinmann, Amy S.
Bcl-6 directly represses the gene program of the glycolysis pathway
title Bcl-6 directly represses the gene program of the glycolysis pathway
title_full Bcl-6 directly represses the gene program of the glycolysis pathway
title_fullStr Bcl-6 directly represses the gene program of the glycolysis pathway
title_full_unstemmed Bcl-6 directly represses the gene program of the glycolysis pathway
title_short Bcl-6 directly represses the gene program of the glycolysis pathway
title_sort bcl-6 directly represses the gene program of the glycolysis pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226759/
https://www.ncbi.nlm.nih.gov/pubmed/25194422
http://dx.doi.org/10.1038/ni.2985
work_keys_str_mv AT oestreichkennethj bcl6directlyrepressesthegeneprogramoftheglycolysispathway
AT readkaitlina bcl6directlyrepressesthegeneprogramoftheglycolysispathway
AT gilbertsonsarahe bcl6directlyrepressesthegeneprogramoftheglycolysispathway
AT houghkennethp bcl6directlyrepressesthegeneprogramoftheglycolysispathway
AT mcdonaldpaulw bcl6directlyrepressesthegeneprogramoftheglycolysispathway
AT krishnamoorthyveena bcl6directlyrepressesthegeneprogramoftheglycolysispathway
AT weinmannamys bcl6directlyrepressesthegeneprogramoftheglycolysispathway