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Bcl-6 directly represses the gene program of the glycolysis pathway
Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription fac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226759/ https://www.ncbi.nlm.nih.gov/pubmed/25194422 http://dx.doi.org/10.1038/ni.2985 |
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author | Oestreich, Kenneth J. Read, Kaitlin A. Gilbertson, Sarah E. Hough, Kenneth P. McDonald, Paul W. Krishnamoorthy, Veena Weinmann, Amy S. |
author_facet | Oestreich, Kenneth J. Read, Kaitlin A. Gilbertson, Sarah E. Hough, Kenneth P. McDonald, Paul W. Krishnamoorthy, Veena Weinmann, Amy S. |
author_sort | Oestreich, Kenneth J. |
collection | PubMed |
description | Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription factor Bcl-6 directly repressed genes involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm2 and Hk2, in T(H)1 cells exposed to low amounts of interleukin 2 (IL-2). Thus, Bcl-6 plays an opposing role to the IL-2-sensitive glycolytic transcriptional program that c-Myc and HIF-1α promote in effector T cells. Additionally, the Th1-lineage-specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes in the glycolysis pathway, implicating the molecular balance between these two factors in metabolic gene program regulation. |
format | Online Article Text |
id | pubmed-4226759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-42267592015-04-01 Bcl-6 directly represses the gene program of the glycolysis pathway Oestreich, Kenneth J. Read, Kaitlin A. Gilbertson, Sarah E. Hough, Kenneth P. McDonald, Paul W. Krishnamoorthy, Veena Weinmann, Amy S. Nat Immunol Article Despite our increasing knowledge of the molecular events that induce the glycolysis pathway in effector T cells, very little is known about the transcriptional mechanisms that dampen the glycolysis program in quiescent cell populations such as memory T cells. Here, we show that the transcription factor Bcl-6 directly repressed genes involved in the glycolysis pathway, including Slc2a1, Slc2a3, Pkm2 and Hk2, in T(H)1 cells exposed to low amounts of interleukin 2 (IL-2). Thus, Bcl-6 plays an opposing role to the IL-2-sensitive glycolytic transcriptional program that c-Myc and HIF-1α promote in effector T cells. Additionally, the Th1-lineage-specifying factor T-bet functionally antagonized the Bcl-6-dependent repression of genes in the glycolysis pathway, implicating the molecular balance between these two factors in metabolic gene program regulation. 2014-09-07 2014-10 /pmc/articles/PMC4226759/ /pubmed/25194422 http://dx.doi.org/10.1038/ni.2985 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Oestreich, Kenneth J. Read, Kaitlin A. Gilbertson, Sarah E. Hough, Kenneth P. McDonald, Paul W. Krishnamoorthy, Veena Weinmann, Amy S. Bcl-6 directly represses the gene program of the glycolysis pathway |
title | Bcl-6 directly represses the gene program of the glycolysis pathway |
title_full | Bcl-6 directly represses the gene program of the glycolysis pathway |
title_fullStr | Bcl-6 directly represses the gene program of the glycolysis pathway |
title_full_unstemmed | Bcl-6 directly represses the gene program of the glycolysis pathway |
title_short | Bcl-6 directly represses the gene program of the glycolysis pathway |
title_sort | bcl-6 directly represses the gene program of the glycolysis pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226759/ https://www.ncbi.nlm.nih.gov/pubmed/25194422 http://dx.doi.org/10.1038/ni.2985 |
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