Cargando…
Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia
There is a positive association between sulfatide and atherosclerosis in an animal model for human familial hypercholesterolemia. Carotid intima–media thickness (IMT) is thought to be a marker of atherosclerosis in humans. We investigated the relationship between sulfatide and carotid IMT in heteroz...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226842/ https://www.ncbi.nlm.nih.gov/pubmed/25173691 http://dx.doi.org/10.1007/s10719-014-9555-5 |
_version_ | 1782343676397092864 |
---|---|
author | Li, Gang Hu, Rui |
author_facet | Li, Gang Hu, Rui |
author_sort | Li, Gang |
collection | PubMed |
description | There is a positive association between sulfatide and atherosclerosis in an animal model for human familial hypercholesterolemia. Carotid intima–media thickness (IMT) is thought to be a marker of atherosclerosis in humans. We investigated the relationship between sulfatide and carotid IMT in heterozygous familial hypercholesterolemia (FH) patients. Thirty-five genetically-verified heterozygous patients with FH and 34 healthy controls were recruited into our study. We measured serum sulfatide levels, the carotid IMT, and conventional cardiovascular risk factors including obesity parameters, blood pressure, fasting blood glucose, and lipid profiles. Subjects with heterozygous FH had significantly elevated serum sulfatide, elevated total cholesterol, low-density lipoprotein cholesterol, and increased carotid IMT compared with control subjects. In patients with FH, univariate analysis showed that serum sulfatide was significantly correlated with carotid IMT. Multiple linear regression analysis indicated that serum sulfatide was the only independent predictor of carotid IMT in patients with FH. Patients with heterozygous FH had significantly higher carotid IMT and the level of serum sulfatide was independently associated with atherosclerotic progression. (R: 0.720, R(2): 0.503, p < 0.001). |
format | Online Article Text |
id | pubmed-4226842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-42268422014-11-13 Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia Li, Gang Hu, Rui Glycoconj J Article There is a positive association between sulfatide and atherosclerosis in an animal model for human familial hypercholesterolemia. Carotid intima–media thickness (IMT) is thought to be a marker of atherosclerosis in humans. We investigated the relationship between sulfatide and carotid IMT in heterozygous familial hypercholesterolemia (FH) patients. Thirty-five genetically-verified heterozygous patients with FH and 34 healthy controls were recruited into our study. We measured serum sulfatide levels, the carotid IMT, and conventional cardiovascular risk factors including obesity parameters, blood pressure, fasting blood glucose, and lipid profiles. Subjects with heterozygous FH had significantly elevated serum sulfatide, elevated total cholesterol, low-density lipoprotein cholesterol, and increased carotid IMT compared with control subjects. In patients with FH, univariate analysis showed that serum sulfatide was significantly correlated with carotid IMT. Multiple linear regression analysis indicated that serum sulfatide was the only independent predictor of carotid IMT in patients with FH. Patients with heterozygous FH had significantly higher carotid IMT and the level of serum sulfatide was independently associated with atherosclerotic progression. (R: 0.720, R(2): 0.503, p < 0.001). Springer US 2014-08-31 2014 /pmc/articles/PMC4226842/ /pubmed/25173691 http://dx.doi.org/10.1007/s10719-014-9555-5 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Li, Gang Hu, Rui Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
title | Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
title_full | Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
title_fullStr | Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
title_full_unstemmed | Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
title_short | Association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
title_sort | association between serum sulfatide and carotid intima media thickness in patients with familial hypercholesterolemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226842/ https://www.ncbi.nlm.nih.gov/pubmed/25173691 http://dx.doi.org/10.1007/s10719-014-9555-5 |
work_keys_str_mv | AT ligang associationbetweenserumsulfatideandcarotidintimamediathicknessinpatientswithfamilialhypercholesterolemia AT hurui associationbetweenserumsulfatideandcarotidintimamediathicknessinpatientswithfamilialhypercholesterolemia |