MSEA: detection and quantification of mutation hotspots through mutation set enrichment analysis

Many cancer genes form mutation hotspots that disrupt their functional domains or active sites, leading to gain- or loss-of-function. We propose a mutation set enrichment analysis (MSEA) implemented by two novel methods, MSEA-clust and MSEA-domain, to predict cancer genes based on mutation hotspot p...

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Detalles Bibliográficos
Autores principales: Jia, Peilin, Wang, Quan, Chen, Qingxia, Hutchinson, Katherine E, Pao, William, Zhao, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226881/
https://www.ncbi.nlm.nih.gov/pubmed/25348067
http://dx.doi.org/10.1186/s13059-014-0489-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226881/
https://www.ncbi.nlm.nih.gov/pubmed/25348067
http://dx.doi.org/10.1186/s13059-014-0489-9

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