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Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis

BACKGROUND: Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious d...

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Autores principales: Feng, Yan, Wang, Fengliang, Pan, Hongqiu, Qiu, Sangsang, Lü, Jieqiong, Wu, Liang, Wang, Jianming, Lu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226896/
https://www.ncbi.nlm.nih.gov/pubmed/25377722
http://dx.doi.org/10.1186/s12879-014-0592-2
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author Feng, Yan
Wang, Fengliang
Pan, Hongqiu
Qiu, Sangsang
Lü, Jieqiong
Wu, Liang
Wang, Jianming
Lu, Cheng
author_facet Feng, Yan
Wang, Fengliang
Pan, Hongqiu
Qiu, Sangsang
Lü, Jieqiong
Wu, Liang
Wang, Jianming
Lu, Cheng
author_sort Feng, Yan
collection PubMed
description BACKGROUND: Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious diseases such as tuberculosis. METHODS: This case-control study included 1625 pulmonary tuberculosis cases and 1570 unaffected controls recruited from the Jiangsu province in China. Single nucleotide polymorphisms (SNPs), rs9939609 and rs8050136, in the FTO gene were genotyped using TaqMan allelic discrimination assays. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the unconditional logistic regression model. RESULTS: We observed a significant association between the genetic polymorphism rs9939609 and tuberculosis risk. Compared with the common genotype TT, individuals carrying AA had a significantly increased risk, with an OR of 3.77 (95% CI: 2.26-6.28). After adjusting for potential confounders, the relationship remains significant. An additive model showed that carriers of an allele A had a 26% increased risk of tuberculosis compared with the T allele (OR: 1.26, 95% CI: 1.08-1.48). Compared with the common haplotype rs9939609T-rs8050136C, the haplotype rs9939609A-rs8050136C was related to an increased risk of tuberculosis (OR = 6.09, 95% CI: 3.27-12.34). CONCLUSIONS: The FTO polymorphism rs9939609 is associated with a risk of pulmonary tuberculosis in the Chinese population.
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spelling pubmed-42268962014-11-12 Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis Feng, Yan Wang, Fengliang Pan, Hongqiu Qiu, Sangsang Lü, Jieqiong Wu, Liang Wang, Jianming Lu, Cheng BMC Infect Dis Research Article BACKGROUND: Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious diseases such as tuberculosis. METHODS: This case-control study included 1625 pulmonary tuberculosis cases and 1570 unaffected controls recruited from the Jiangsu province in China. Single nucleotide polymorphisms (SNPs), rs9939609 and rs8050136, in the FTO gene were genotyped using TaqMan allelic discrimination assays. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the unconditional logistic regression model. RESULTS: We observed a significant association between the genetic polymorphism rs9939609 and tuberculosis risk. Compared with the common genotype TT, individuals carrying AA had a significantly increased risk, with an OR of 3.77 (95% CI: 2.26-6.28). After adjusting for potential confounders, the relationship remains significant. An additive model showed that carriers of an allele A had a 26% increased risk of tuberculosis compared with the T allele (OR: 1.26, 95% CI: 1.08-1.48). Compared with the common haplotype rs9939609T-rs8050136C, the haplotype rs9939609A-rs8050136C was related to an increased risk of tuberculosis (OR = 6.09, 95% CI: 3.27-12.34). CONCLUSIONS: The FTO polymorphism rs9939609 is associated with a risk of pulmonary tuberculosis in the Chinese population. BioMed Central 2014-11-07 /pmc/articles/PMC4226896/ /pubmed/25377722 http://dx.doi.org/10.1186/s12879-014-0592-2 Text en © Feng et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Feng, Yan
Wang, Fengliang
Pan, Hongqiu
Qiu, Sangsang
Lü, Jieqiong
Wu, Liang
Wang, Jianming
Lu, Cheng
Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
title Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
title_full Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
title_fullStr Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
title_full_unstemmed Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
title_short Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
title_sort obesity-associated gene fto rs9939609 polymorphism in relation to the risk of tuberculosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226896/
https://www.ncbi.nlm.nih.gov/pubmed/25377722
http://dx.doi.org/10.1186/s12879-014-0592-2
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