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Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis
BACKGROUND: Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226896/ https://www.ncbi.nlm.nih.gov/pubmed/25377722 http://dx.doi.org/10.1186/s12879-014-0592-2 |
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author | Feng, Yan Wang, Fengliang Pan, Hongqiu Qiu, Sangsang Lü, Jieqiong Wu, Liang Wang, Jianming Lu, Cheng |
author_facet | Feng, Yan Wang, Fengliang Pan, Hongqiu Qiu, Sangsang Lü, Jieqiong Wu, Liang Wang, Jianming Lu, Cheng |
author_sort | Feng, Yan |
collection | PubMed |
description | BACKGROUND: Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious diseases such as tuberculosis. METHODS: This case-control study included 1625 pulmonary tuberculosis cases and 1570 unaffected controls recruited from the Jiangsu province in China. Single nucleotide polymorphisms (SNPs), rs9939609 and rs8050136, in the FTO gene were genotyped using TaqMan allelic discrimination assays. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the unconditional logistic regression model. RESULTS: We observed a significant association between the genetic polymorphism rs9939609 and tuberculosis risk. Compared with the common genotype TT, individuals carrying AA had a significantly increased risk, with an OR of 3.77 (95% CI: 2.26-6.28). After adjusting for potential confounders, the relationship remains significant. An additive model showed that carriers of an allele A had a 26% increased risk of tuberculosis compared with the T allele (OR: 1.26, 95% CI: 1.08-1.48). Compared with the common haplotype rs9939609T-rs8050136C, the haplotype rs9939609A-rs8050136C was related to an increased risk of tuberculosis (OR = 6.09, 95% CI: 3.27-12.34). CONCLUSIONS: The FTO polymorphism rs9939609 is associated with a risk of pulmonary tuberculosis in the Chinese population. |
format | Online Article Text |
id | pubmed-4226896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42268962014-11-12 Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis Feng, Yan Wang, Fengliang Pan, Hongqiu Qiu, Sangsang Lü, Jieqiong Wu, Liang Wang, Jianming Lu, Cheng BMC Infect Dis Research Article BACKGROUND: Obesity is known to affect cell-mediated immune responses. Recent studies have revealed that genetic polymorphisms in the fat mass and obesity associated (FTO) gene are related to human obesity. We hypothesize that this gene may also play a role in the risk of immune-related infectious diseases such as tuberculosis. METHODS: This case-control study included 1625 pulmonary tuberculosis cases and 1570 unaffected controls recruited from the Jiangsu province in China. Single nucleotide polymorphisms (SNPs), rs9939609 and rs8050136, in the FTO gene were genotyped using TaqMan allelic discrimination assays. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the unconditional logistic regression model. RESULTS: We observed a significant association between the genetic polymorphism rs9939609 and tuberculosis risk. Compared with the common genotype TT, individuals carrying AA had a significantly increased risk, with an OR of 3.77 (95% CI: 2.26-6.28). After adjusting for potential confounders, the relationship remains significant. An additive model showed that carriers of an allele A had a 26% increased risk of tuberculosis compared with the T allele (OR: 1.26, 95% CI: 1.08-1.48). Compared with the common haplotype rs9939609T-rs8050136C, the haplotype rs9939609A-rs8050136C was related to an increased risk of tuberculosis (OR = 6.09, 95% CI: 3.27-12.34). CONCLUSIONS: The FTO polymorphism rs9939609 is associated with a risk of pulmonary tuberculosis in the Chinese population. BioMed Central 2014-11-07 /pmc/articles/PMC4226896/ /pubmed/25377722 http://dx.doi.org/10.1186/s12879-014-0592-2 Text en © Feng et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Feng, Yan Wang, Fengliang Pan, Hongqiu Qiu, Sangsang Lü, Jieqiong Wu, Liang Wang, Jianming Lu, Cheng Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis |
title | Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis |
title_full | Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis |
title_fullStr | Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis |
title_full_unstemmed | Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis |
title_short | Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis |
title_sort | obesity-associated gene fto rs9939609 polymorphism in relation to the risk of tuberculosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226896/ https://www.ncbi.nlm.nih.gov/pubmed/25377722 http://dx.doi.org/10.1186/s12879-014-0592-2 |
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